The Drosophila suppressor of underreplication protein binds to late-replicating regions of polytene chromosomes.

Genetics
Igor V MakuninIgor F Zhimulev

Abstract

In many late-replicating euchromatic regions of salivary gland polytene chromosomes, DNA is underrepresented. A mutation in the SuUR gene suppresses underreplication and leads to normal levels of DNA polytenization in these regions. We identified the SuUR gene and determined its structure. In the SuUR mutant stock a 6-kb insertion was found in the fourth exon of the gene. A single SuUR transcript is present at all stages of Drosophila development and is most abundant in adult females and embryos. The SuUR gene encodes a protein of 962 amino acids whose putative sequence is similar to the N-terminal part of SNF2/SWI2 proteins. Staining of salivary gland polytene chromosomes with antibodies directed against the SuUR protein shows that the protein is localized mainly in late-replicating regions and in regions of intercalary and pericentric heterochromatin.

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Citations

Aug 16, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·E N AndreyevaI F Zhimulev
Apr 20, 2005·Oncogene·Mary A Lilly, Robert J Duronio
Mar 1, 2006·Current Opinion in Genetics & Development·Michaela Schwaiger, Dirk Schübeler
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stepan N BelyakinIgor F Zhimulev
Dec 11, 2007·Doklady. Biochemistry and Biophysics·O V PosukhI F Zhimulev
Oct 28, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Igor F Zhimulev, Elena S Belyaeva
Aug 12, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Harald BiessmannJames M Mason
Oct 13, 2005·Chromosoma·Julie A Wallace, Terry L Orr-Weaver
Feb 11, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hugh W Brock, Cynthia L Fisher
Jul 4, 2007·Journal of Cell Science·Alexey V PindyurinIgor F Zhimulev
May 1, 2008·Journal of Cell Science·Alexey V PindyurinIgor F Zhimulev
Nov 24, 2005·Nature Reviews. Genetics·Luca Comai
Jan 2, 2004·The Journal of Biological Chemistry·Nickolai A TchurikovIvan A Zykov
Feb 24, 2009·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Nicole C RiddleSarah C R Elgin
Aug 5, 2009·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·E B KokozaI F Zhimulev
Nov 30, 2016·Genes & Development·Jessica L Alexander, Terry L Orr-Weaver
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Nov 24, 2021·Genome Research·Matthew M EdwardsAmnon Koren
Sep 20, 2011·Chromosoma·Tin Tin Su
Jan 10, 2012·Development·Jared Nordman, Terry L Orr-Weaver

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