PMID: 8951796Oct 1, 1996Paper

The Drosophila teashirt homeotic protein is a DNA-binding protein and modulo, a HOM-C regulated modifier of variegation, is a likely candidate for being a direct target gene

Mechanisms of Development
E AlexandreB Jacq

Abstract

The Drosophila teashirt (tsh) gene has an homeotic function which, in combination with HOM-C genes, determines thoracic and abdominal (trunk) identities. Analysis of TSH protein distribution during embryogenesis using a specific polyclonal antibody shows that it is nuclear. The protein is present with regional modulation in several tissues within the trunk, suggesting additional tsh functions to those already studied. We identified a candidate tsh target shared with some HOM-C genes, the modifier of variegation gene modulo (mod). The TSH zinc-finger protein recognizes in vitro two specific sites within a 5' control element of the mod gene which responds in vivo to tsh activity. TSH is therefore a DNA binding protein and might directly control mod expression.

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Citations

Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·S ChauvetY Graba
Apr 4, 2009·PloS One·Yuji KajiwaraJoseph D Buxbaum
Mar 16, 2013·American Journal of Medical Genetics. Part a·Paul R MarkChad R Haldeman-Englert
Jun 30, 2011·Genesis : the Journal of Genetics and Development·Timothy EricksonAndrew J Waskiewicz
Sep 21, 2010·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Vincent J Lynch, Günter P Wagner
Jan 11, 2002·Developmental Biology·Corinne AngelatsStephen Kerridge
Nov 6, 2004·Gene·Shiwani SharmaNeil G Della
Oct 13, 2006·Gene Expression Patterns : GEP·Han WangQiaoming Long
Jun 28, 2005·Current Opinion in Genetics & Development·James W Mahaffey
Jul 2, 2003·Mechanisms of Development·Laurent PerrinJacques Montagne
Jun 24, 2008·Developmental Biology·Javier TerrienteFernando J Díaz-Benjumea
Jun 26, 2007·Developmental Biology·Nathalie CoréLaurent Fasano
Aug 19, 2006·Developmental Biology·Katja KoebernickDoris Wedlich
Jul 6, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S ChauvetD Aragnol
Nov 21, 2009·Journal of the American Society of Nephrology : JASN·Claire M LyeAdrian S Woolf
Sep 5, 2015·The Journal of Biological Chemistry·Jeremy M SimonSamantha G Pattenden

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