PMID: 8951789Oct 1, 1996Paper

The Drosophila TGF-alpha-like protein Gurken: expression and cellular localization during Drosophila oogenesis

Mechanisms of Development
F S Neuman-Silberberg, T Schüpbach

Abstract

The establishment of anterior-posterior and dorsal-ventral polarity of the Drosophila egg and embryo depends on the function of the genes gurken, cornichon and Egfr (Drosophila epidermal growth factor receptor homolog). These genes encode components of a signal transduction pathway that transmits information between the germline cells and the somatic follicle cells of the ovary. gurken encodes a transforming growth factor-alpha-like protein and is a putative germline ligand of the Egfr present on the follicle cells. In mid-oogenesis the gurken transcript becomes spatially localized to the future dorsal-anterior cortex of the oocyte. To analyze the distribution pattern of Gurken protein we prepared antibodies against Gurken. We describe here the distribution pattern of the Gurken protein in wild-type ovaries and in ovaries from a number of dorsal-ventral patterning mutants. By immunoblotting we detect one major form of the Gurken protein, which likely corresponds to the unprocessed protein.

References

Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R GangulyR Krishnan
Apr 21, 1995·Cell·D St Johnston
Mar 1, 1994·Genes & Development·L B Christerson, D M McKearin
Mar 1, 1996·Trends in Genetics : TIG·C Rongo, R Lehmann
Mar 1, 1978·Wilhelm Roux's Archives of Developmental Biology·Eric WieschausWalter Gehring

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Citations

May 2, 2001·The Anatomical Record·D R HaudenschildF Binette
Jun 15, 2007·Development Genes and Evolution·Fabio BernardiGiuseppe Gargiulo
May 1, 1997·Trends in Genetics : TIG·R Schweitzer, B Z Shilo
Nov 21, 2002·Trends in Cell Biology·Kim L Farina, Robert H Singer
Apr 16, 2011·Zygote : the Biology of Gametes and Early Embryos·M C VaccaroR Carotenuto
Dec 17, 2004·Biology of the Cell·Robert S Cohen
Aug 3, 2011·Molecular & Cellular Proteomics : MCP·Janine KoepkeMichael Feldbrügge
Oct 13, 2006·Molecular and Cellular Biology·Cuiyun Geng, Paul M Macdonald
Sep 21, 2001·Molecular and Cellular Biology·N Aoyagi, D A Wassarman
Nov 1, 2001·Annual Review of Cell and Developmental Biology·I M Palacios, D St Johnston
Mar 28, 2007·BMC Developmental Biology·Michelle K Smith, Barbara T Wakimoto
Oct 23, 2012·BMC Genomics·Cathy CharlierJulien Bobe
Feb 28, 2008·Journal of Cell Science·Angela M JaramilloTrudi Schupbach
Dec 24, 2011·Journal of Cell Science·Laura R SerbusWilliam Sullivan
Mar 29, 2014·PLoS Computational Biology·Adrien FauréClaudine Chaouiya
May 9, 2014·Disease Models & Mechanisms·Suvi VartiainenHoward T Jacobs
Jan 10, 2002·Biochemical and Biophysical Research Communications·Kenji IwaiHirohei Yamamura
Nov 29, 2013·Molecular Biology of the Cell·Andrew J SpracklenTina L Tootle
Apr 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ai Khim Lim, Toshie Kai
Jul 30, 2014·Annual Review of Cell and Developmental Biology·Maria IvshinaJoel D Richter
Sep 12, 2000·Current Opinion in Genetics & Development·H D Lipshitz, C A Smibert
Feb 9, 2010·Cellular and Molecular Life Sciences : CMLS·Serena DuchiGiuseppe Gargiulo
Oct 11, 2011·Cellular and Molecular Life Sciences : CMLS·Karen Shahbabian, Pascal Chartrand
Aug 9, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ashim MukherjeeJohn R Nambu
Apr 6, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Josefa Steinhauer, Daniel Kalderon
May 12, 2007·Genesis : the Journal of Genetics and Development·F Shira Neuman-Silberberg
Aug 16, 2014·Wiley Interdisciplinary Reviews. Developmental Biology·David S Stein, Leslie M Stevens
Jul 28, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Amanda NorvellLetitia Thompson
Feb 28, 2002·Biochemical and Biophysical Research Communications·Anat ShmueliF Shira Neuman-Silberberg

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