The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease

Oxidative Medicine and Cellular Longevity
Ya-Dan WenYi Zhun Zhu

Abstract

The recognition of hydrogen sulfide (H2S) has been evolved from a toxic gas to a physiological mediator, exhibiting properties similar to NO and CO. On the one hand, H2S is produced from L-cysteine by enzymes of cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3MST) in combination with aspartate aminotransferase (AAT) (also called as cysteine aminotransferase, CAT); on the other hand, H2S is produced from D-cysteine by enzymes of D-amino acid oxidase (DAO). Besides sulfide salt, several sulfide-releasing compounds have been synthesized, including organosulfur compounds, Lawesson's reagent and analogs, and plant-derived natural products. Based on garlic extractions, we synthesized S-propargyl-L-cysteine (SPRC) and its analogs to contribute our endeavors on drug development of sulfide-containing compounds. A multitude of evidences has presented H2S is widely involved in the roles of physiological and pathological process, including hypertension, atherosclerosis, angiogenesis, and myocardial infarcts. This review summarizes current sulfide compounds, available H2S measurements, and potential molecular mechanisms involved in cardioprotections to help researchers develop further a...Continue Reading

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Citations

Mar 7, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Gopi K KolluruChristopher G Kevil
Aug 28, 2020·Frontiers in Microbiology·Say Yong NgWilfried Moreira
Apr 4, 2021·Antioxidants·Valerio CicconeLucia Morbidelli
Jun 1, 2021·Clinical Hemorheology and Microcirculation·Maria FornalTomasz Grodzicki
Jul 3, 2021·International Journal of Molecular Sciences·Shuangyu LvHonggang Wang
Jul 9, 2021·Fitoterapia·Christian J Valencia-GuzmánCésar Ibarra-Alvarado
Aug 8, 2021·International Journal of Molecular Sciences·Chien-Ning Hsu, You-Lin Tain
Aug 7, 2021·Frontiers in Pharmacology·Wout VerbeurePeter R van Dijk
Aug 24, 2021·Frontiers in Cellular and Infection Microbiology·Zhou WangYi Zhun Zhu
Aug 10, 2021·Molecular Medicine Reports·Hu ZhangNannan Guo

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Methods Mentioned

BETA
pharmacotherapy
coronary artery bypass
transgenic
chemical modification
MDA

Clinical Trials Mentioned

NCT00879645
NCT00858936

Software Mentioned

PHSS
CouMC

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