The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans.

European Archives of Psychiatry and Clinical Neuroscience
S TrostOliver Gruber

Abstract

DTNBP1 is one of the most established susceptibility genes for schizophrenia, and hippocampal volume reduction is one of the major neuropathological findings in this severe disorder. Consistent with these findings, the encoded protein dysbindin-1 has been shown to be diminished in glutamatergic hippocampal neurons in schizophrenic patients. The aim of this study was to investigate the effects of two single nucleotide polymorphisms of DTNBP1 on grey matter volumes in human subjects using voxel-based morphometry. Seventy-two subjects were included and genotyped with respect to two single nucleotide polymorphisms of DTNBP1 (rs2619522 and rs1018381). All participants underwent structural magnetic resonance imaging (MRI). MRI data were preprocessed and statistically analysed using standard procedures as implemented in SPM5 (Statistical Parametric Mapping), in particular the voxel-based morphometry (VBM) toolbox. We found significant effects of the DTNBP1 SNP rs2619522 bilaterally in the hippocampus as well as in the anterior middle frontal gyrus and the intraparietal cortex. Carriers of the G allele showed significantly higher grey matter volumes in these brain regions than T/T homozygotes. Compatible with previous findings on a rol...Continue Reading

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Citations

Jan 12, 2013·European Archives of Psychiatry and Clinical Neuroscience·Andrea Schmitt, Peter Falkai
Dec 20, 2015·Journal of Neurochemistry·Nathalie SchmiegClotilde Mannoury la Cour
Feb 14, 2013·Schizophrenia Research·Vanessa K OtaAndrea P Jackowski
Jun 25, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ayla Arslan
Sep 25, 2017·International Journal of Molecular Sciences·Haitao WangWenhua Zheng
Jan 13, 2018·International Journal of Molecular Sciences·Ayla Arslan
May 8, 2018·Brain Structure & Function·Hildegard JanouschekThomas Nickl-Jockschat
Aug 26, 2021·Stem Cells·Abinaya ChandrasekaranKristine K Freude

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Methods Mentioned

BETA
PCR
PCRs
environmental stress

Software Mentioned

SPM5
MATLAB

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