The dual actions of Paederia scandens extract as a hypouricemic agent: xanthine oxidase inhibitory activity and uricosuric effect

Planta medica
Hai-Yan YanLanlan Zhou

Abstract

Hyperuricemia is associated with a number of pathological conditions, such as gout. Lowering of elevated uric acid levels in the blood could be achieved by xanthine oxidase inhibitors and inhibitors of renal urate reabsorption. Some natural compounds isolated from herbs used in traditional Chinese medicine have been previously demonstrated to act as xanthine oxidase inhibitors. In the present investigation, Paederia scandens (Lour.) Merrill (Rubiaceae) extract (PSE; 4.5, 2.25, and 1.125 g/kg) orally for 14 days was demonstrated to possess in vivo potent hypouricemic activity in hyperuricemic rats pretreated with potassium oxonate. In addition, PSE was also demonstrated to be an inhibitor of xanthine oxidase. Lineweaver-Burk analysis of the enzyme kinetics indicated that the inhibition of PSE was of a mixed type. Using an oxonate-induced hyperuricemic rat model, PSE was indeed shown to exhibit uricosuric action in vivo, which could explain, at least in part, the observed hypouricemic effect of PSE in these rats. The potential application of this compound in the treatment of conditions associated with hyperuricemia is discussed.

Citations

Jun 22, 2010·American Journal of Therapeutics·Andrew Whelton
Aug 31, 2010·Journal of Ethnopharmacology·Jaroslav HavlikVojtech Rada
Nov 12, 2014·The American Journal of Chinese Medicine·Zhao-Qing MengZhong-Lin Yang
Nov 30, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shi-xiang HouLan-lan Zhou

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