The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes

Gene
Manouchehr NakhjavaniAlireza Esteghamati

Abstract

Experimental evidence suggests that heat shock proteins (HSP) and asymmetric dimethylarginine (ADMA) are induced in the state of chronic inflammation and stress conditions. They are both inhibitors of nitric oxide synthase (NOS). The aim of this study was to evaluate the correlation between ADMA and HSP70, in patients with type 2 diabetes with respect to serum levels of C reactive protein (CRP). We quantified serum HSP70, ADMA and CRP in 80 newly-diagnosed patients with type 2 diabetes plus 80 age-, sex and BMI-matched healthy controls. The patients and controls were also stratified into groups of high and low CRP levels (cut-point: 2.5mg/ml). Patients with type 2 diabetes had significantly higher serum HSP70 (0.52 [0.51-0.66] vs. 0.27 [0.26-0.36], p<0.001), ADMA (0.86 [0.81-0.92] vs. 0.72 [0.71-0.85], p<0.05) and CRP (2.9 [1.7-3.4] vs. 1.6[1.2-2.3], p<0.05) compared with healthy controls. Serum HSP70 and ADMA levels were significantly correlated in patients with high CRP levels (r=0.89, p<0.01), whereas there were no correlation in patients with low CRP (r=-0.37, p=0.07) and controls. This correlation was significant (r=0.77, p<0.001) in patients with high CRP and also in patients with low CRP levels (r=-0.51, p<0.05), after m...Continue Reading

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Citations

May 18, 2013·Cell Stress & Chaperones·Afsaneh MortezaAlireza Esteghamati
Jul 28, 2012·Diagnostic Pathology·Mohamed Yahia HriraAbdelhedi Miled
Feb 14, 2014·Cell Stress & Chaperones·Philip L HooperLaszlo Vigh
Oct 23, 2012·The International Journal of Biochemistry & Cell Biology·Marta González-RamosDiego Rodríguez-Puyol
Feb 28, 2015·Cell Stress & Chaperones·Zoltán GaramvölgyiAttila Molvarec
Jan 22, 2015·Meta Gene·Manouchehr NakhjavaniAlireza Esteghamati
Dec 6, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Graham Pockley, Brian Henderson
Dec 15, 2017·International Journal of Molecular Sciences·Stefania BelliniGabriella Gruden
Aug 28, 2021·Journal of Clinical Medicine·Zohaib IqbalAdrian H Heald

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