The dual effect of C-peptide on cellular activation and atherosclerosis: Protective or not?

Diabetes/metabolism Research and Reviews
Michelle Teodoro AlvesKarina Braga Gomes

Abstract

C-peptide is a cleavage product of proinsulin that acts on different type of cells, such as blood and endothelial cells. C-peptide biological effects may be different in type 1 and type 2 diabetes. Besides, there are further evidence for a functional interaction between C-peptide and insulin. In this way, C-peptide has ambiguous effects, acting as an antithrombotic or thrombotic molecule, depending on the physiological environment and disease conditions. Moreover, C-peptide regulates interaction of leucocytes, erythrocytes, and platelets with the endothelium. The beneficial effects include stimulation of nitric oxide production with its subsequent release by platelets and endothelium, the interaction with erythrocytes leading to the generation of adenosine triphosphate, and inhibition of atherogenic cytokine release. The undesirable action of C-peptide includes the chemotaxis of monocytes, lymphocytes, and smooth muscle cells. Also, C-peptide was related with increased lipid deposits and elevated smooth muscle cells proliferation in the vessel wall, contributing to atherosclerosis. Purpose of this review is to explore these dual roles of C-peptide on the blood, contributing at one side to haemostasis and the other to atheroscle...Continue Reading

References

Sep 1, 1978·Diabetes·D E McMillanJ La Puma
Jul 5, 1990·The New England Journal of Medicine·J R VaneR M Botting
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T S LeeG L King
Dec 1, 1995·The American Journal of Physiology·M L EllsworthH H Dietrich
Sep 12, 1998·Kidney International·M SjöquistB L Johansson
Oct 31, 1998·Vascular Medicine·J L Wautier, P J Guillausseau
Mar 8, 2000·American Journal of Hematology·S L SpaceJ V Weil
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·L H YoungA M Lefer
Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R ScaliaA M Lefer
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 13, 2002·Circulation·Johann W AuerBernd Eber
Mar 1, 2003·Clinical Science·Daniela ManzellaGiuseppe Paolisso
Jun 12, 2003·American Journal of Physiology. Endocrinology and Metabolism·Bo-Lennart JohanssonJohn Pernow
Sep 5, 2003·American Journal of Physiology. Endocrinology and Metabolism·Bo-Lennart JohanssonJuhani Knuuti
Oct 11, 2003·Biochemical and Biophysical Research Communications·Heiko Mühl, Josef Pfeilschifter
Nov 19, 2003·Nitric Oxide : Biology and Chemistry·Thomas WallerathUlrich Förstermann
Jan 25, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Björn SamnegårdMats Sjöquist
Jul 22, 2005·Clinical Science·Casper G Schalkwijk, Coen D A Stehouwer
Dec 20, 2007·Diabetes/metabolism Research and Reviews·Akihiro KamikawaKazuhiro Kimura
Mar 1, 2008·Trends in Cardiovascular Medicine·Nikolaus Marx
Mar 20, 2008·Experimental Diabetes Research·Karin Ekberg, Bo-Lennart Johansson
May 17, 2008·Experimental Diabetes Research·Thomas HachJohn Wahren
Oct 29, 2008·Clinical and Experimental Pharmacology & Physiology·Francis I Achike
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Patricio López-JaramilloMarcos López
Apr 18, 2009·Cellular and Molecular Life Sciences : CMLS·M AleksicN Marx

❮ Previous
Next ❯

Citations

Oct 13, 2019·Life Sciences·Habib YaribeygiAmirhossein Sahebkar
Jul 16, 2021·The American Journal of Chinese Medicine·Ya-Xin ZhangFeng-Hua Zhou
Aug 31, 2021·Frontiers in Endocrinology·Ziwei ChenMingbing Xiao

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

International Journal of Inflammation
Dusica Vasic, Daniel Walcher
The Review of Diabetic Studies : RDS
Daniel Walcher, Nikolaus Marx
Seikagaku. The Journal of Japanese Biochemical Society
Kazuhiro Kimura
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
J MarkussenF Sundby
© 2022 Meta ULC. All rights reserved