PMID: 6982343Jan 1, 1982Paper

The dual effect of rubidium ions on potassium efflux in depolarized frog skeletal muscle

The Journal of Membrane Biology
B C SpaldingP Horowicz

Abstract

The effects of external Rb+ on the efflux of 42K+ from whole frog sartorius muscles loaded with 305 mM K+ and 120 mM Cl- were studied. K+ efflux is activated by [Rb+]o less than about 40 mM according to a sigmoid relation similar to that for activation by [K+]o. At [Rb+]o greater than 40 mM, K+ efflux declines, although at [Rb+]o = 300 mM it is still greater than at [Rb+]o = 0 mM. For low concentrations, the increment in K+ efflux over that in K+-and Rb+-free solution, delta K, is described by the relation delta k = a[X+]on, for both K+ and Rb+. The value of a is larger for Rb+ than for K+, while the values of n are similar; the activation produced by a given [Rb+]o is larger than that by an equal [K+]o for concentrations less than about 40 mM. Adding a small amount of Rb+ to a K+-containing solution has effects on K+ efflux which depend on [K+]o. At low [K+]o, adding Rb+ increases K+ efflux, the effect being greatest near [K+]o = 30 mM and declining at higher [K+]o; at [K+]o above 40 mM, addition of Rb+ decreases K+ efflux. At [K+]o above 75 mM, where K+ efflux is largely activated, Rb+ reduces K+ efflux by a factor b, described by the relation b = 1/(1+c[Rb+]o). Activation is discussed in terms of binding to at least two site...Continue Reading

References

Oct 1, 1978·The Journal of General Physiology·B Hille, W Schwarz
Jun 1, 1973·The Journal of General Physiology·B Hille
Jun 1, 1973·The Journal of General Physiology·A M Woodhull
Jul 1, 1970·The Journal of Physiology·R H AdrianA L Hodgkin
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·H OhmoriS Hagiwara
Jul 1, 1981·The American Journal of Physiology·B C SpaldingP Horowicz
Jul 1, 1980·The Journal of Physiology·N B Standen, P R Stanfield
Dec 1, 1964·The Journal of Physiology·R H ADRIAN
Oct 1, 1959·The Journal of Physiology·A L HODGKIN, P HOROWICZ

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Citations

Apr 1, 1990·The Journal of Membrane Biology·B A Kotsias, P Horowicz
Jan 1, 1986·The Journal of Membrane Biology·B C SpaldingP Horowicz
Apr 1, 1994·The Journal of General Physiology·M R SilverT E DeCoursey
Feb 1, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Donald T Haynie

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