The dual probiotic and antibiotic nature of Bdellovibrio bacteriovorus

BMB Reports
Mohammed DwidarRobert J Mitchell


Bdellovibrio bacteriovorus is a predatory bacterium which attacks and consumes other bacterial strains, including the well known pathogens E. coli O157 : H7, Salmonella typhimurium and Helicobacter pylori. This remarkable activity has been the focus of research for nearly five decades, with exciting practical applications to medical, agriculture and farming practices recently being published. This article reviews many of the exciting steps research into this bacterium, and similar bacteria, has taken, focusing primarily on their use as both an antibiotic to remove harmful and pathogenic bacteria and as a probiotic to help curb and control the bacterial populations within the intestinal tract. Owing to the unique and dual nature of this bacterium, this review proposes the use of "amphibiotic" to describe these bacteria and their activities.


Nov 1, 1977·Applied and Environmental Microbiology·J M Westergaard, T T Kramer
Apr 1, 1976·Applied and Environmental Microbiology·J C Fry, D G Staples
Aug 21, 1992·Science·H C Neu
Jul 1, 1990·The Journal of Applied Bacteriology·I R Richardson
Aug 1, 1968·Canadian Journal of Biochemistry·F J Simpson, J Robinson
Dec 1, 1972·The American Journal of Clinical Nutrition·M Nakamura
Jun 1, 1996·Journal of Industrial Microbiology·M M DoolittleD E Caldwell
Jul 21, 2001·Lancet·Philip S Stewart, J W Costerton
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R GuerreroL Margulis
Aug 28, 2002·International Journal of Medical Microbiology : IJMM·Philip S Stewart
Nov 28, 2002·Journal of Dental Research·Jorma Tenovuo
Apr 25, 2003·Poultry Science·J A Patterson, K M Burkholder
Nov 25, 2003·Nature·Thien-Fah MahGeorge A O'Toole
Dec 23, 2003·Environmental Microbiology·Yair Shemesh, Edouard Jurkevitch
May 22, 2004·Caries Research·A Van Nieuw AmerongenE C I Veerman
Jul 21, 2004·Nature Reviews. Microbiology·R Elizabeth Sockett, Carey Lambert
Jul 8, 2005·Applied and Environmental Microbiology·Daniel E Kadouri, George A O'Toole
Jul 6, 2006·Applied and Environmental Microbiology·Heather A O'ConnellEric S Gilbert
Mar 13, 2009·Journal of Dental Research·M Van EsscheWim Teughels
Mar 28, 2009·The Lancet Infectious Diseases·Patrice NordmannThierry Naas
Dec 7, 2010·Trends in Biotechnology·Thomas K WoodQun Ma
Jan 11, 2011·Molecular Oral Microbiology·A Dashiff, Daniel E Kadouri
Jan 11, 2011·Molecular Oral Microbiology·M Van EsscheW Teughels
Jun 28, 2011·Applied and Environmental Microbiology·Robert J AtterburyRenee Elizabeth Sockett
Jan 1, 1995·Microbial Ecology·H N WilliamsW A Falkler
Feb 1, 1995·Journal of Food Protection·Pina M Fratamico, Richard C Whiting


Jun 21, 2013·PloS One·Mohammed DwidarRobert J Mitchell
Feb 21, 2014·Journal of Indian Society of Periodontology·K HariniShruthi Hegde
Dec 13, 2012·Future Microbiology·Eric C Keen
May 9, 2014·Future Microbiology·Robert M Q Shanks, Daniel E Kadouri
Oct 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Or RotemEdouard Jurkevitch
Jan 1, 2015·Microorganisms·Riccardo RussoNancy D Connell
Jun 24, 2014·Annals of the New York Academy of Sciences·Heather K AllenThomas A Casey
Dec 15, 2015·Environmental Microbiology·Juana PérezJosé Muñoz-Dorado
Aug 7, 2013·Water Research·Eun-Ho KimYoung-Nam Kwon
Mar 12, 2015·Surgical Infections·Sandeep KathjuPaul Stoodley
Aug 17, 2016·Scientific Reports·Eric G RomanowskiRobert M Q Shanks
Sep 16, 2016·Scientific Reports·Ajay K MonnappaRobert J Mitchell
Sep 1, 2016·PloS One·Shilpi GuptaDaniel E Kadouri
Mar 7, 2017·Scientific Reports·Kenneth ShatzkesDaniel E Kadouri
Mar 29, 2014·Environmental Microbiology·Mohammed DwidarRobert J Mitchell
Dec 30, 2015·Applied and Environmental Microbiology·Somdatta MukherjeeDaniel E Kadouri
Nov 12, 2016·MBio·Kenneth ShatzkesDaniel E Kadouri
Nov 22, 2015·Applied and Environmental Microbiology·Gary P RichardsMichael A Watson
Mar 21, 2018·Genes & Nutrition·Bastian HornungPeter J Schaap
Jun 13, 2019·Microbial Ecology·Julia JohnkeHinrich Schulenburg
Apr 26, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Lekshmi NarendrakumarSabu Thomas
Sep 10, 2019·Environmental Microbiology·Hansol ImRobert J Mitchell
May 17, 2017·Current Protocols in Microbiology·Mélanie J BoileauKenneth D Clinkenbeard
Oct 9, 2019·Advanced Pharmaceutical Bulletin·Fataneh Hashempour-BaltorkMatin Alizadeh
Feb 16, 2019·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Hayk Minasyan
Mar 17, 2020·Applied Microbiology and Biotechnology·Robert J MitchellSeong Yeol Choi
Apr 27, 2017·FEMS Microbiology Letters·Julia JohnkeAntonis Chatzinotas
May 14, 2017·Scientific Reports·Kenneth ShatzkesNancy D Connell
Sep 5, 2019·Frontiers in Microbiology·Xiaoyan CuiHong Du
May 1, 2020·Frontiers in Microbiology·Eleni BratanisEwa Bukowska-Faniband
Oct 10, 2020·Computational and Structural Biotechnology Journal·Juana PérezJosé Muñoz-Dorado
Feb 6, 2021·Journal of Applied Microbiology·Suman DasNabendu Sekhar Chatterjee

Related Concepts

Interference, Bacterial
Escherichia coli
Salmonella typhimurium
Helicobacter pylori
Bdellovibrio bacteriovorus

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.