The dual role of interferon-gamma in experimental Staphylococcus aureus septicaemia versus arthritis

Immunology
Y X ZhaoA Tarkowski

Abstract

To evaluate the role of interferon-gamma (IFN-gamma) in Staphylococcus aureus infection, we investigated the effects of supplementation with and neutralization of IFN-gamma during septicaemia and arthritis in a murine model. In vivo administration of IFN-gamma both before and after bacterial inoculation significantly decreased mortality on one hand but enhanced the development of arthritis on the other. Treatment of mice with anti-IFN-gamma monoclonal antibodies (mAb) before and after bacterial inoculation did not significantly influence the survival rate but decreased the frequency and severity of arthritis. The beneficial effect of supplementation with IFN-gamma on septicaemia was correlated to the increased phagocytosis and bacterial clearance from liver and kidneys. The down-regulation of the development of arthritis by anti-IFN-gamma mAb was accompanied by the decreased serum tumour necrosis factor-alpha, interleukin-6 and interleukin-1 beta levels. These results demonstrate a significant role for IFN-gamma in simultaneous protection against septicaemia but promotion for the development of septic arthritis.

References

Aug 1, 1992·The Journal of Infectious Diseases·A T Silva, J Cohen
Aug 1, 1991·Infection and Immunity·T BremellA Tarkowski
Jan 1, 1990·International Journal of Immunopharmacology·H MatsumuraM Nakano
Sep 1, 1990·Clinical and Experimental Immunology·H NakajimaW Tsukada
Oct 1, 1988·Arthritis and Rheumatism·N J MauritzL Klareskog
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N A Buchmeier, R D Schreiber
Dec 1, 1993·The Journal of Experimental Medicine·J L FlynnB R Bloom
Apr 1, 1995·Trends in Microbiology·J Verhoef, E Mattsson
Dec 1, 1993·The Journal of Experimental Medicine·A M CooperI M Orme
Jan 1, 1993·Annual Review of Immunology·M A Farrar, R D Schreiber

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Citations

Aug 21, 2003·Microbial Pathogenesis·Inger GjertssonAndrej Tarkowski
Jul 13, 2000·Cellular Signalling·J M ElleryP J Nicholls
Oct 29, 2002·Cellular Signalling·Susanne BellKorbinian Brand
Jul 4, 2001·Trends in Microbiology·A TarkowskiM Verdrengh
Jun 28, 2002·British Journal of Pharmacology·D P Crosara-AlbertoF Q Cunha
Feb 13, 2008·The Journal of Experimental Medicine·Juliane Bubeck Wardenburg, Olaf Schneewind
Oct 13, 2006·Current Opinion in Infectious Diseases·H Hilbi
Aug 9, 2002·Shock·Zhengwu Sun, Roland Andersson
Sep 21, 2004·Shock·Pierre Moine, Edward Abraham
Feb 24, 2000·Journal of Periodontal Research·E Josefsson, A Tarkowski
Oct 5, 2002·Clinical Microbiology Reviews·Mark E Shirtliff, Jon T Mader
Jun 30, 2010·Infection and Immunity·Louise HenningssonInger Gjertsson
Aug 19, 2007·American Journal of Respiratory and Critical Care Medicine·Michal A OlszewskiGalen B Toews
Feb 15, 2001·Arthritis Research·O H HultgrenA Tarkowski
Feb 14, 2002·Archives of Biochemistry and Biophysics·Anne-Laure BulteauBertrand Friguet
Jul 15, 1999·Clinical and Experimental Immunology·N NilssonH Carlsten
Nov 28, 2002·Clinical and Experimental Immunology·I GjertssonA Tarkowski
May 14, 2014·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Priscila Maria Colavite, Alexandrina Sartori
Oct 30, 2015·Applied Microbiology and Biotechnology·Man WangJianguo Zhu
May 12, 2009·Immunology Letters·Sara Elena SatorresMaria Silvia Di Genaro
Nov 28, 2006·Best Practice & Research. Clinical Rheumatology·Andrej Tarkowski
Mar 25, 2005·European Journal of Immunology·Shauna CulshawIain B McInnes
Oct 10, 2006·Vaccine·Marie-Claude GaudreauBrian G Talbot
Jul 9, 2002·The Journal of Infection·S MandalS J Peacock
Aug 13, 2013·The Journal of Infection·Maria BergquistCatharina Lindholm
Sep 19, 2014·PLoS Neglected Tropical Diseases·Aline Alves de Lima SilvaCarla Pagliari
Feb 1, 2008·PLoS Medicine·Martin RottmanJean-Laurent Casanova

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