The Duesseldorf warning signs for primary immunodeficiency: is it time to change the rules?

Journal of Clinical Immunology
Petra LankischHans-Jürgen Laws

Abstract

Different sets of warning signs can be used if primary immunodeficiency (PID) is suspected: those of the Jeffrey Modell Foundation (JMF), the German Patients' Organisation for Primary Immunodeficiencies (DSAI) and the Association of the Scientific Medical Societies in Germany (AWMF). A few studies have tested the JMF criteria, with unconvincing results, but the diagnostic models of the DSAI and AWMF have not been tested at all. We set out to establish the utility of these three scoring systems and compare them with our own set of five warning signs (Duesseldorf criteria). Prospective study. Two hundred ten patients admitted to our hospital between 2010 and 2012 with suspected PID. PID were found in 36 (17 %) of the patients admitted. Of the established sets of warning signs, the JMF and the DSAI had inadequate sensitivity, while the DSAI and the AWMF showed insufficient specificity. Our own criteria were analyzed with regard to maximal specificity and sensitivity (Youden Index) and sensitivity and yielded NPV of 0.89 and 0.91 respectively. Youden index revealed combination of five signs and symptoms: lymphopenia, otitis media >7, failure to thrive, failure to grow normally, pneumonia >1. For maximum negative predictive value th...Continue Reading

References

Apr 18, 2000·HNO·V Wahn
Aug 10, 2006·Clinical Trials : Journal of the Society for Clinical Trials·Chaya S Moskowitz, Margaret S Pepe
Jun 15, 2007·Clinical and Experimental Immunology·P WoodUNKNOWN UK Primary Immunodeficiency Network
Jun 20, 2007·Journal of Clinical Immunology·J M Boyle, R H Buckley
Oct 22, 2009·Clinical and Experimental Immunology·B GathmannUNKNOWN ESID Registry Working Party
Apr 1, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Andrew MacGinnitieSeema Mishra
Apr 5, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Magda Carneiro-SampaioCléa Rodrigues Leone
Apr 13, 2011·Pediatrics·Anbezhil SubbarayanPeter D Arkwright
Nov 5, 2011·Klinische Pädiatrie·S FarmandUNKNOWN Association of the Scientific Medical Societies in Germany (AWMF)
Dec 2, 2011·Annals of the New York Academy of Sciences·Peter D Arkwright, Andrew R Gennery
Aug 1, 2012·Journal of Clinical Immunology·Ahmed Aziz BousfihaLaurent Abel
Oct 12, 2012·Journal of Clinical Immunology·Mohammad S EhlayelMohammad Abu Laban
Dec 27, 2012·The World Allergy Organization Journal·Salem Al-TamemiDavid Dennison
Mar 2, 2013·Allergy, Asthma & Immunology Research·Shereen M RedaHanaa M Afifi
Apr 24, 2013·Clinical and Experimental Immunology·B GathmannG Kindle
Mar 5, 2014·Nature Reviews. Clinical Oncology·Lisa Hutchinson

❮ Previous
Next ❯

Citations

Jan 28, 2016·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sevket ArslanIsmail Baloglu
Sep 2, 2017·Children·Egidio BarbiBaruch S Krauss
Sep 29, 2019·Inflammatory Bowel Diseases·Judith R KelsenMarcella Devoto
Aug 9, 2020·Paediatrics & Child Health·Paul Tsoukas, Ronald M Laxer
Dec 29, 2015·Current Allergy and Asthma Reports·Lori Broderick
Jun 16, 2017·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ashleigh R PaveyBenjamin D Solomon
Nov 6, 2020·Current Opinion in Pediatrics·Juan C Aldave-BecerraClaudia A Rentería-Valdiviezo
Nov 12, 2020·Jornal de pediatria·Fernanda Pinto-Mariz
Apr 26, 2021·The Journal of Allergy and Clinical Immunology·Julian ThalhammerUNKNOWN European Society for Immunodeficiencies Registry Working Party

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Langenbecks Archiv für Chirurgie. Supplement. Kongressband
K H Vosteen
American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
Michael D KellerJordan S Orange
Ugeskrift for laeger
Jørgen Hels
© 2022 Meta ULC. All rights reserved