The duration of action of bupivacaine, levobupivacaine, ropivacaine and pethidine in peripheral nerve block in the rat

Acta Anaesthesiologica Scandinavica
H DyhreH Renck

Abstract

There is a current interest in local anaesthetic drugs/formulations exhibiting long durations of sensory block and minor motor-blocking effects. To compare the duration of sensory and motor blockade in peripheral nerve blocks induced by the new agents ropivacaine and levobupivacaine, with that of racemic bupivacaine and pethidine. Groups of 8 male Sprague-Dawley rats were subjected to infraorbital (IONB) or sciatic nerve block (SNB) employing 0.2 ml of differently concentrated solutions of bupivacaine, levobupivacaine, ropivacaine or pethidine. The sensory blocking effect in IONB is expressed as (i) the time to elicitation of an abdominal jerk by electrical stimulation at arbitrarily chosen (threshold) intensities (IONB degree 3, 5, 8 and 10), and as (ii) the area under the curve (AUC, threshold intensities vs time). The duration of motor block in SNB is given as the time from injection to regained ability to walk and grip normally with the toes. Comparisons of the dose-effect relationships for the investigated agents were made by analysis of covariance. In IONB the log (dose)-log (effect) lines for bupivacaine, levobupivacaine and ropivacaine did not deviate from parallelism. The duration of sensory block induced by equimolar ...Continue Reading

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Citations

Aug 10, 2000·Anesthesiology Clinics of North America·J C Crews
Apr 13, 2001·Acta Anaesthesiologica Scandinavica·D A McNameeK R Milligan
Jun 5, 2001·La Revue du praticien·D Fletcher
Oct 3, 2006·Current Opinion in Anaesthesiology·L E Mather, S R Edwards
Apr 1, 2011·Regional Anesthesia and Pain Medicine·Lavinia M Kolarczyk, Brian A Williams
Feb 10, 2011·Anesthesia and Analgesia·Marcio G KiuchiRoberto T Sudo
Apr 7, 2006·Anesthesia Progress·Maria Cristina VolpatoFrancisco Carlos Groppo
Nov 14, 2014·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jonathan F BovaMandi J Lopez
Jul 5, 2005·Expert Opinion on Investigational Drugs·R W Gristwood, J L Greaves
Dec 21, 2010·Research in Veterinary Science·Rafael DeRossiAndrea C L de Barros
Apr 18, 2003·Anesthesiology Clinics of North America·Moeen Panni, Scott Segal
Jun 22, 2005·Best Practice & Research. Clinical Anaesthesiology·Andrea Casati, Marta Putzu
Mar 23, 2010·International Journal of Surgery·Sin Leong Yong, Paul Coulthard
Aug 5, 2008·Regional Anesthesia and Pain Medicine·Maki MizogamiKo Takakura
Aug 29, 2003·Regional Anesthesia and Pain Medicine·Catherine J Sinnott, Gary R Strichartz
Apr 24, 2019·Investigative Ophthalmology & Visual Science·Ian D MengNeal E Mecum
Dec 25, 2013·Journal of Orthopaedic Surgery·Panagiotis TheodosiadisByron Chalidis
Jan 7, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Jin-Young ParkKyung-Soo Oh
Jan 20, 2005·Equine Veterinary Journal·L A BidwellH M Clayton
Jan 7, 2017·JBJS Reviews·Richard HowellMary K Mulcahey

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