The duration of impairment of autonomic control after anticholinergic drug administration in humans

Anesthesia and Analgesia
J L ParlowM J Odell

Abstract

Impaired parasympathetic control of heart rate is associated with increased incidence of cardiac dysrhythmias and ischemia. Anticholinergic drugs, commonly administered during reversal of neuromuscular blockade, suppress parasympathetic control in the early postoperative period. This could potentially be detrimental in patients at risk of cardiovascular complications. The duration of parasympathetic impairment by two anticholinergic drugs were compared in this double-blind randomized cross-over study. Fourteen healthy volunteers received a single intravenous injection of atropine 20 micrograms/kg or glycopyrrolate 8 micrograms/kg during two different study sessions. The methods of spontaneous baroreflex analysis and spectral analysis of heart rate variability generated indices of beat-by-beat parasympathetic modulation of heart rate. Both drugs resulted in a marked decrease in baroreflex sensitivity and high-frequency heart rate variability. The times to return to baseline values were approximately doubled after atropine compared to glycopyrrolate (177 +/- 22 vs 82 +/- 8 min for baroreflex sensitivity, 212 +/- 16 vs 111 +/- 14 min for high-frequency power, and 171 +/- 18 vs 95 +/- 18 min for high-frequency power normalized to t...Continue Reading

References

Jul 1, 1992·Journal of Clinical Anesthesia·T W LatsonJ M Lipton
Jul 1, 1991·Acta Anaesthesiologica Scandinavica·T Ali-MelkkiläE Iisalo
Aug 1, 1989·Acta Anaesthesiologica Scandinavica·T Ali-MelkkiläJ Kanto
Jan 1, 1988·European Journal of Clinical Pharmacology·E C Meyer, D K Sommers
Feb 1, 1988·Acta Anaesthesiologica Scandinavica·J Kanto, U Klotz
Nov 1, 1983·British Journal of Clinical Pharmacology·D Preiss, P Berguson

❮ Previous
Next ❯

Citations

Oct 1, 2008·Acta Anaesthesiologica Scandinavica·A CividjianL Quintin
Aug 19, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Marcin BujakCarlos Mena
Apr 4, 2017·International Journal of Pharmaceutics·Tamás SohajdaLajos Szente
Jul 3, 2008·Journal of the American Veterinary Medical Association·Andrea L LooneyUNKNOWN Association of Shelter Veterinarians' Spay and Neuter Task Force
Oct 27, 2001·Journal of Autonomic Pharmacology·J PenttiläH Scheinin
Sep 9, 2004·Acta Anaesthesiologica Scandinavica·M Tanaka, T Nishikawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.