The duration of pre-ovulatory serum progesterone elevation before hCG administration affects the outcome of IVF/ICSI cycles

Human Reproduction
Chu-Chun HuangYu-Shih Yang

Abstract

During controlled ovarian stimulation (COS), does the duration of premature serum progesterone (P) elevation before administration of hCG affect the outcomes of IVF/ICSI embryo transfer (-ET) cycles? The duration of the premature serum P elevation is inversely related to the clinical pregnancy rate of IVF/ICSI-ET cycles. The majority of the previous studies only considered a single serum P measurement made on the day of hCG administration and the results of attempts to relate this to IVF/ICSI-ET outcomes were controversial. However, the effect of the duration of premature serum P elevation before the hCG administration on the outcomes of IVF/ICSI-ET cycles has not been studied well. Here we demonstrate that the duration of premature serum P elevation has a more significant inverse correlation than the absolute serum P concentration on the day of hCG administration with IVF/ICSI-ET outcomes. It is a retrospective, single-centre cohort study. A total of 1784 IVF and/or ICSI-ET cycles were included from October 2005 to June 2011. A total of 1784 patients underwent their IVF and/or ICSI-ET cycles in a university hospital IVF unit. The inclusion criteria include (i) age between 20 and 42 years and (ii) eligible indications for COS b...Continue Reading

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Citations

Jan 22, 2013·Human Reproduction·Keith Gordon, Barbara J Stegmann
Dec 20, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jiongjiong TuFei Gong
Dec 15, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Berfu DemirLeyla Mollamahmutoglu
Apr 16, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ying ChenHongbo Qi
Jan 25, 2016·Reproductive Biomedicine Online·Lawrence EngmannPeter Humaidan
Jun 14, 2014·Reproductive Biomedicine Online·Charlotte SonigoJean-Noel Hugues
Aug 1, 2016·Reproductive Biomedicine Online·Chin-Der ChenShee-Uan Chen
Jan 14, 2017·Journal of Assisted Reproduction and Genetics·Jennifer K BlakemoreJamie Grifo
Jul 15, 2015·Clinical and Experimental Reproductive Medicine·Ju Hee ParkSeok Hyun Kim
Dec 6, 2019·Human Reproduction·Christophe BlockeelAnja Pinborg
Feb 26, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yavuz Emre ŞükürMurat Sönmezer
Jul 28, 2018·Journal of Assisted Reproduction and Genetics·Apostolos KaponisGeorge Decavalas
Oct 28, 2019·Journal of Assisted Reproduction and Genetics·Reda S HusseinYulian Zhao
Jan 25, 2020·Seminars in Reproductive Medicine·Gurkan BozdagHakan Yarali
Jan 2, 2021·Reproductive Biomedicine Online·Mathilde BourdonPietro Santulli

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