The dynamic changes in the number of uterine natural killer cells are specific to the eutopic but not to the ectopic endometrium in women and in a baboon model of endometriosis

Reproductive Biology and Endocrinology : RB&E
Josephine A DruryDharani K Hapangama

Abstract

Endometriosis is a common condition associated with growth of endometrial-like tissue beyond the uterine cavity. Previous reports have suggested a role for uNK cells in the pathogenesis of endometriosis postulating that survival and accumulation of menstrual endometrial tissue in the peritoneal cavity may relate to a reduction in the cytotoxic activity of peripheral blood NK cells. We aimed to assess the differences in percentage of uNK cells and their phenotypical characterization in eutopic and ectopic endometrial samples from women with and without endometriosis and baboons with induced endometriosis. Eutopic and ectopic endometrial samples from 82 women across the menstrual cycle with/without endometriosis and from 8 baboons before and after induction of endometriosis were examined for CD56 and NKp30 expression with immunohistochemistry, quantified using computer assisted image analysis. Curated secretory phase endometrial microarray datasets were interrogated for NK cell receptors and their ligands. In silico data was validated by examining the secretory phase eutopic endometrium of women with and without endometriosis (n = 8/group) for the immuno-expression of BAG6 protein. The percentage of uNK cells increased progressiv...Continue Reading

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Citations

Sep 22, 2019·Journal of Clinical Medicine·Aneta ŚcieżyńskaJacek Malejczyk
Jul 2, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Mine Islimye TaskinLevent Elmas
May 16, 2020·International Journal of Reproductive Medicine·Alison MacleanDharani K Hapangama
Nov 14, 2019·International Journal of Molecular Sciences·Carlo TicconiAsgerally Fazleabas
Jun 4, 2019·Frontiers in Oncology·Rafah A A AlnafakhDharani K Hapangama
Aug 20, 2019·Human Reproduction Update·Júlia Vallvé-JuanicoLinda C Giudice
May 29, 2021·Cell·Philippa T K Saunders, Andrew W Horne
Jul 4, 2021·Tissue & Cell·Carlo TicconiAsgerally Fazleabas
Jul 3, 2021·Cells·Dorota M Radomska-LeśniewskaPaweł Kamiński
Jul 18, 2021·Reproductive Biomedicine Online·Shay FregerWarren George Foster
Feb 8, 2022·Fertility and Sterility·Hilde JørgensenLinda Griffith

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Methods Mentioned

BETA
biopsies

Software Mentioned

Illumina BaseSpace Correlation Engine
Image J

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