The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4

Journal of the American Chemical Society
Jeyaprakashnarayanan SeenisamyL H Hurley

Abstract

The nuclease hypersensitivity element III1 (NHE III1) upstream of the P1 and P2 promoters of c-MYC controls 80-90% of the transcriptional activity of this gene. The purine-rich strand in this region can form a G-quadruplex structure that is a critical part of the silencer element for this promoter. We have demonstrated that this G-quadruplex structure can form a mixture of four biologically relevant parallel-loop isomers, which upon interaction with the cationic porphyrin TMPyP4 are converted to mixed parallel/antiparallel G-quadruplex structures.

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Citations

Jan 27, 2011·Analytical and Bioanalytical Chemistry·Jiangtao RenJin Wang
Jun 21, 2006·Biochemistry·Himesh FernandoShankar Balasubramanian
Aug 16, 2008·Biochemistry·Himesh FernandoShankar Balasubramanian
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Jul 27, 2006·Journal of the American Chemical Society·Jeremy J GreenShankar Balasubramanian
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