The dynamic genome: transposons and environmental adaptation in the nervous system

Epigenomics
Hannah E Lapp, Richard G Hunter

Abstract

Classically thought as genomic clutter, the functional significance of transposable elements (TEs) has only recently become a focus of attention in neuroscience. Increasingly, studies have demonstrated that the brain seems to have more retrotransposition and TE transcription relative to other somatic tissues, suggesting a unique role for TEs in the central nervous system. TE expression and transposition also appear to vary by brain region and change in response to environmental stimuli such as stress. TEs appear to serve a number of adaptive roles in the nervous system. The regulation of TE expression by steroid, epigenetic and other mechanisms in interplay with the environment represents a significant and novel avenue to understanding both normal brain function and disease.

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Feb 21, 2018·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Peter A LarsenAnn M Saunders
Jun 3, 2020·Integrative and Comparative Biology·Richard G Hunter
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Aug 6, 2021·Annals of the New York Academy of Sciences·Tara L White, Meghan A Gonsalves

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Methods Mentioned

BETA
environmental stress
acetylation

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