The dynamic interplay between DNA topoisomerases and DNA topology

Biophysics Reviews
Yeonee Seol, Keir C Neuman

Abstract

Topological properties of DNA influence its structure and biochemical interactions. Within the cell, DNA topology is constantly in flux. Transcription and other essential processes, including DNA replication and repair, not only alter the topology of the genome but also introduce additional complications associated with DNA knotting and catenation. These topological perturbations are counteracted by the action of topoisomerases, a specialized class of highly conserved and essential enzymes that actively regulate the topological state of the genome. This dynamic interplay among DNA topology, DNA processing enzymes, and DNA topoisomerases is a pervasive factor that influences DNA metabolism in vivo. Building on the extensive structural and biochemical characterization over the past four decades that has established the fundamental mechanistic basis of topoisomerase activity, scientists have begun to explore the unique roles played by DNA topology in modulating and influencing the activity of topoisomerases. In this review we survey established and emerging DNA topology-dependent protein-DNA interactions with a focus on in vitro measurements of the dynamic interplay between DNA topology and topoisomerase activity.

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Citations

Dec 6, 2018·Nucleic Acids Research·Dmitry SutorminKonstantin Severinov
Dec 20, 2018·Nucleic Acids Research·Phoolwanti Rani, Valakunja Nagaraja
May 17, 2017·Biophysics Reviews·Cris Dos Remedios
Dec 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natassja G BushAnthony Maxwell
May 9, 2021·Nucleic Acids Research·Dian SpakmanGraeme A King

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