The Dynamic Nature of Hypertrophic and Fibrotic Remodeling of the Fish Ventricle

Frontiers in Physiology
Adam N KeenHolly A Shiels

Abstract

Chronic pressure or volume overload can cause the vertebrate heart to remodel. The hearts of fish remodel in response to seasonal temperature change. Here we focus on the passive properties of the fish heart. Building upon our previous work on thermal-remodeling of the rainbow trout ventricle, we hypothesized that chronic cooling would initiate fibrotic cardiac remodeling, with increased myocardial stiffness, similar to that seen with pathological hypertrophy in mammals. We hypothesized that, in contrast to pathological hypertrophy in mammals, the remodeling response in fish would be plastic and the opposite response would occur following chronic warming. Rainbow trout held at 10°C (control group) were chronically (>8 weeks) exposed to cooling (5°C) or warming (18°C). Chronic cold induced hypertrophy in the highly trabeculated inner layer of the fish heart, with a 41% increase in myocyte bundle cross-sectional area, and an up-regulation of hypertrophic marker genes. Cold acclimation also increased collagen deposition by 1.7-fold and caused an up-regulation of collagen promoting genes. In contrast, chronic warming reduced myocyte bundle cross-sectional area, expression of hypertrophic markers and collagen deposition. Functionall...Continue Reading

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Citations

Dec 23, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ahmed BadrMatti Vornanen
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Nov 18, 2021·Journal of the Royal Society, Interface·Adam N KeenHolly A Shiels

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Datasets Mentioned

BETA
AY009126.1

Methods Mentioned

BETA
atomic force microscopy
PCR
light microscopy
AFM

Software Mentioned

Nanoscope Analysis
ImageJ
Nanoscope
SigmaPlot
R
SYSTAT

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