The dynamic nature of systems consolidation: Stress during learning as a switch guiding the rate of the hippocampal dependency and memory quality

Hippocampus
Lizeth K PedrazaLucas de Oliveira Alvares

Abstract

Memory fades over time, becoming more schematic or abstract. The loss of contextual detail in memory may reflect a time-dependent change in the brain structures supporting memory. It has been well established that contextual fear memory relies on the hippocampus for expression shortly after learning, but it becomes hippocampus-independent at a later time point, a process called systems consolidation. This time-dependent process correlates with the loss of memory precision. Here, we investigated whether training intensity predicts the gradual decay of hippocampal dependency to retrieve memory, and the quality of the contextual memory representation over time. We have found that training intensity modulates the progressive decay of hippocampal dependency and memory precision. Strong training intensity accelerates systems consolidation and memory generalization in a remarkable timeframe match. The mechanisms underpinning such process are triggered by glucocorticoid and noradrenaline released during training. These results suggest that the stress levels during emotional learning act as a switch, determining the fate of memory quality. Moderate stress will create a detailed memory, whereas a highly stressful training will develop a ...Continue Reading

References

May 1, 1969·Journal of Comparative and Physiological Psychology·R J Blanchard, D C Blanchard
Apr 1, 1995·Current Opinion in Neurobiology·L R Squire, P Alvarez
Sep 11, 1999·Trends in Neurosciences·E R de KloetM Joëls
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·B RoozendaalJ L McGaugh
Jan 15, 2000·Science·J L McGaugh
Jul 13, 2002·Journal of Affective Disorders·B M Elzinga, J D Bremner
Aug 3, 2002·The Journal of Neuropsychiatry and Clinical Neurosciences·Barry Layton, Robert Krikorian
Aug 13, 2002·Stress : the International Journal on the Biology of Stress·M Isabel CorderoCarmen Sandi
Jan 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Benno RoozendaalJames L McGaugh
Jan 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Shoki OkudaJames L McGaugh
Jan 28, 2004·Annual Review of Psychology·Yadin Dudai
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Akinobu SuzukiSatoshi Kida
Jul 3, 2004·Science·Thibault MavielBruno Bontempi
Sep 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benno RoozendaalJames L McGaugh
Oct 7, 2004·Learning & Memory·María Eugenia PedreiraHéctor Maldonado
Feb 3, 2005·Nature Reviews. Neuroscience·Paul W Frankland, Bruno Bontempi
Apr 7, 2005·Neuroscience and Biobehavioral Reviews·E Ronald de KloetMathias Schmidt
Dec 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter J BayleyLarry R Squire
May 25, 2007·Learning & Memory·Brian J Wiltgen, Alcino J Silva
Dec 7, 2007·Neural Plasticity·Carmen Sandi, M Teresa Pinelo-Nava
Feb 16, 2008·Science·Jeffrey D Karpicke, Henry L Roediger
May 30, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Silvia G BustosVíctor A Molina
Feb 3, 2009·Nature Neuroscience·Szu-Han WangPaul W Frankland
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Patrizia CampolongoVincenzo Cuomo
Apr 4, 2009·Frontiers in Neuroendocrinology·Dominique J-F de QuervainBenno Roozendaal
Mar 30, 2010·Learning & Memory·Lucas de Oliveira AlvaresJorge Alberto Quillfeldt
Jul 20, 2010·Current Biology : CB·Brian J WiltgenAlcino J Silva
Oct 5, 2010·Learning & Memory·Basira SalehiCarmen Sandi
Oct 19, 2010·Trends in Cognitive Sciences·Henry L Roediger, Andrew C Butler
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria Carmen IndaCristina M Alberini
Apr 5, 2011·Annual Review of Neuroscience·Larry R Squire, John T Wixted
Jul 7, 2011·Journal of the International Neuropsychological Society : JINS·Gordon Winocur, Morris Moscovitch
Nov 29, 2011·Hippocampus·Lucas de Oliveira AlvaresJorge Alberto Quillfeldt
Nov 30, 2011·Behavioral Neuroscience·Benno Roozendaal, James L McGaugh
Feb 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Piray AtsakBenno Roozendaal
Mar 1, 2012·Science·Nadia KaouaneAline Desmedt

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Citations

Nov 20, 2016·The European Journal of Neuroscience·Lars Schwabe
Feb 11, 2016·Hippocampus·Josue HaubrichJorge Alberto Quillfeldt
Oct 9, 2018·Hippocampus·Pamela Lopes da CunhaHaydée Ana María Viola
Feb 28, 2020·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Christopher J KilbyViviana M Wuthrich
Jul 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Svenja Brodt, Steffen Gais
May 10, 2018·Scientific Reports·Lizeth K PedrazaLucas de Oliveira Alvares
Jul 10, 2021·Neurobiology of Learning and Memory·Moisés Dos Santos CorrêaRaquel Vecchio Fornari
Dec 17, 2015·Learning & Memory·Enmanuelle Pardilla-DelgadoJessica D Payne

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