The dynamic relationship between antibiotic use and the incidence of vancomycin-resistant Enterococcus: time-series modelling of 7-year surveillance data in a tertiary-care hospital

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
E I KritsotakisA Gikas

Abstract

The role of antibiotics in the epidemiology of vancomycin-resistant Enterococcus (VRE) has been studied extensively, but controversies remain as to which, and to what extent, antibiotics facilitate the emergence and dissemination of VRE in hospitals. Aggregate data on the use of several antibiotic classes in terms of defined daily doses (DDD) per 100 patient-days (PD), and VRE incidence rates in terms of clinical isolates per 1000 PD, were evaluated during a 7-year period at a tertiary-care hospital. Time-series analysis (autoregressive integrated moving average (ARIMA) and transfer function models) was used to quantify the temporal effect of antibiotic use on VRE incidence and estimate effect-delays. The incidence rate of VRE observed in a specific bimester was found to be a function of its value during the preceding bimester and of prior changes in the volume of use of four antibiotic classes. In particular, an increase of one DDD/100 PD in the use of glycopeptides, fluoroquinolones, extended-spectrum cephalosporins and beta-lactam-beta-lactamase inhibitor combinations resulted, independently, in average changes of +0.024, +0.015, + 0.020 and -0.010 isolates per 1000 PD in the incidence of VRE, with average delays of 2, 4, 2 ...Continue Reading

References

May 1, 1994·American Journal of Public Health·J S Koopman, I M Longini
Nov 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J QualeK Patel
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S BonhoefferB R Levin
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·D J AustinR M Anderson
Mar 9, 2000·The New England Journal of Medicine·B E Murray
Mar 16, 2000·International Journal of Antimicrobial Agents·J M López-LozanoM Saez
Aug 7, 2001·Annals of Internal Medicine·S K FridkinUNKNOWN Intensive Care Antimicrobial Resistance Epidemiology (ICARE) Project and the National Nosocomial Infections Surveillance (NN
Oct 6, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S HarbarthM H Samore
Mar 7, 2002·Microbes and Infection·Brett D Shepard, Michael S Gilmore
May 7, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D L MonnetN Gonzalo
May 23, 2002·Antimicrobial Agents and Chemotherapy·Stephan HarbarthYehuda Carmeli
Oct 22, 2004·Emerging Infectious Diseases·Dominique L MonnetIan M Gould
Nov 4, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A ChristidouY Tselentis
Mar 12, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A MahamatA Sotto
Jun 15, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E M Mascini, M J M Bonten
Jun 29, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emilian Armeanu, Marc J M Bonten
Nov 8, 2005·Journal of Clinical Microbiology·Achilleas GikasYannis Tselentis
Jul 18, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E I Kritsotakis, A Gikas

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Citations

Nov 2, 2012·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·I KlareG Werner
Oct 26, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M L MorettiP Trabasso
Apr 8, 2010·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Olivier MaillardDidier Lepelletier
Aug 29, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sevilay TopcuogluGuner Karatekin
May 15, 2013·American Journal of Infection Control·Elias IosifidisEmmanuel Roilides
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P Muñoz, UNKNOWN AST Infectious Diseases Community of Practice
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Isaac SeeShelley S Magill
Jun 7, 2012·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·James A McKinnellLoren G Miller
Jan 24, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Klaus Kaier
Feb 22, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·A NateghianM Navidnia
Feb 25, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Klaus KaierElisabeth Meyer
Sep 20, 2017·Antimicrobial Resistance and Infection Control·Cornelius RemschmidtFrank Schwab
Feb 25, 2017·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·J PochhammerM Schäffer
Nov 13, 2021·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Simon BrinkwirthRobby Markwart

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