PMID: 10319783May 13, 1999Paper

The dynamic relationship between end-tidal sevoflurane and isoflurane concentrations and bispectral index and spectral edge frequency of the electroencephalogram

Anesthesiology
E Olofsen, A Dahan

Abstract

Inhalational anesthetics produce dose-dependent effects on electroencephalogram-derived parameters, such as 95% spectral edge frequency (SEF) and bispectral index (BIS). The authors analyzed the relationship between end-tidal sevoflurane and isoflurane concentrations (FET) and BIS and SEF and determined the speed of onset and offset of effect (t1/2k(e0)). Twenty-four patients with American Society of Anesthesiologists physical status I or II were randomly assigned to receive anesthesia with sevoflurane or isoflurane. Several transitions between 0.5 and 1.5 minimum alveolar concentration were performed. BIS and SEF data were analyzed with a combination of an effect compartment and an inhibitory sigmoid Emax model, characterized by t1/2k(e0), the concentration at which 50% depression of the electroencephalogram parameters occurred (IC50), and shape parameters. Parameter values estimated are mean +/- SD. The model adequately described the FET-BIS relationship. Values for t1/2k(e0), derived from the BIS data, were 3.5 +/- 2.0 and 3.2 +/- 0.7 min for sevoflurane and isoflurane, respectively (NS). Equivalent values derived from SEF were 3.1 +/- 2.4 min (sevoflurane) and 2.3 +/- 1.2 min (isoflurane; NS). Values of t1/2k(e0) derived fr...Continue Reading

References

Mar 1, 1979·Clinical Pharmacology and Therapeutics·L B SheinerJ Ham
Mar 1, 1991·Anesthesia and Analgesia·N YasudaN A Peterson
Apr 1, 1984·Journal of Pharmacokinetics and Biopharmaceutics·D R StanskiE Meathe
Nov 1, 1994·Journal of Clinical Monitoring·J C Sigl, N G Chamoun
May 1, 1993·Anesthesia and Analgesia·H A SeifertJ B Gross
Feb 1, 1996·British Journal of Anaesthesia·W W Mapleson
Jan 1, 1997·Journal of Pharmaceutical Sciences·S DuttaW F Ebling
Oct 20, 1998·Anesthesiology·I J Rampil

❮ Previous
Next ❯

Citations

Nov 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M NakayamaA Namiki
Apr 6, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Nathalie NathanPierre Feiss
May 29, 2007·Der Anaesthesist·S KreuerT Bouillon
Mar 27, 2003·Journal of Clinical Anesthesia·Shigeki YamaguchiToshimitsu Kitajima
Aug 31, 2012·British Journal of Anaesthesia·G B DrummondR R Kennedy
Jan 5, 2002·Anesthesia and Analgesia·Diederik NieuwenhuijsAlbert Dahan
May 25, 2004·Anesthesia and Analgesia·Simon D Whyte, Peter D Booker
Dec 24, 2004·Anesthesia and Analgesia·Terri G MonkJeffrey C Sigl
Feb 24, 2006·Anesthesia and Analgesia·Deborah J CulleyGregory Crosby
Apr 17, 2012·Anesthesia and Analgesia·Gordon B DrummondR Ross Kennedy
Jul 15, 2003·American Journal of Veterinary Research·María F Martín-CanchoJesús Usón-Gargallo
Oct 15, 2008·British Journal of Anaesthesia·E OlofsenA Dahan
Nov 21, 2014·BMC Research Notes·Yoshihide TeradaTakashi Matsukawa
Jan 27, 2006·Journal of Clinical Monitoring and Computing·P Ruiz-GimenoG Aguilar
Mar 28, 2008·Journal of Clinical Monitoring and Computing·Sascha KreuerWolfram Wilhelm
Jul 27, 2011·Journal of Clinical Monitoring and Computing·Gracee AgrawalStephane Bibian
Sep 10, 2013·Best Practice & Research. Clinical Anaesthesiology·Richard K EllerkmannSascha Kreuer
Aug 5, 2009·Current Opinion in Anaesthesiology·Ben Julian A PalancaMichael S Avidan
Sep 24, 2009·Current Opinion in Anaesthesiology·Christopher D Kent, Karen B Domino
Mar 17, 2000·Anesthesiology·N G Chamoun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.