The dynamic serotonin system of the maternal brain

Archives of Women's Mental Health
Joseph S Lonstein

Abstract

Many pregnant and postpartum women worldwide suffer from high anxiety and/or depression, which can have detrimental effects on maternal and infant well-being. The first-line pharmacotherapies for prepartum and postpartum affective disorders continue to be the selective serotonin reuptake inhibitors (SSRIs), despite the lack of large well-controlled studies demonstrating their efficacy in reproducing women and the potential for fetal/neonatal exposure to the drugs. Prepartum or postpartum use of SSRIs or other drugs that modulate the brain's serotonin system is also troubling because very little is known about the typical, let alone the atypical, changes that occur in the female central serotonin system across reproduction. We do know from a handful of studies of women and female laboratory rodents that numerous aspects of the central serotonin system are naturally dynamic across reproduction and are also affected by pregnancy stress (a major predisposing factor for maternal psychopathology). Thus, it should not be assumed that the maternal central serotonin system being targeted by SSRIs is identical to non-parous females or males. More information about the normative and stress-derailed changes in the maternal central serotoni...Continue Reading

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Citations

Nov 2, 2019·Journal of Psychosocial Nursing and Mental Health Services·Barbara J Limandri
Jul 11, 2019·Archives of Women's Mental Health·Jodi Pawluski, Molly Dickens
Oct 11, 2020·Frontiers in Neuroendocrinology·Pilyoung Kim
Mar 18, 2019·Frontiers in Neuroendocrinology·Jodi L PawluskiJoseph S Lonstein
Apr 3, 2021·Current Opinion in Pediatrics·Samuel M ShoversRenee M Turchi
Dec 6, 2021·Neuroscience and Biobehavioral Reviews·Jodi L PawluskiJoseph S Lonstein

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