PMID: 7537427Jan 1, 1995Paper

The dynamics of beta 1 integrin expression during peripheral nerve regeneration

Acta Neuropathologica
H S TaskinenM Röyttä

Abstract

The aim of the present study was to examine the expression of beta 1 integrin subunit after peripheral nerve transection. After sciatic nerve transection two experimental procedures were used; changes in the freely regenerating rat sciatic nerve were compared to a situation in which spontaneous regeneration was prevented by suturing both ends of the nerve to the muscle next to the point of transection. Specimens for morphological analysis were collected 6 h, 1, 3, 5, 7 days and 2, 4, 6 and 8 weeks after the axotomy. Sections from the proximal (two zones) and distal (three zones) stumps next to the point of transection were stained with antibodies against beta 1 integrin subunit, macrophages, collagen types I and III, and S-100 protein. The control nerves showed beta 1 integrin-stained cells in the perineurium and vasa nervorum but the endoneurium was negative. Positively stained endoneurial fibroblast-like cells could be seen in the proximal part of the nerve already at 24 h after transection. The number of these positively stained cells increased steadily; they were most numerous 4 weeks after transection in the distal zone 2. Subsequently, the number of positively stained endoneural cells declined sharply and 8 weeks after tr...Continue Reading

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Citations

Jan 8, 2000·Journal of Neuroimmunology·H S TaskinenM Röyttä
Mar 16, 2001·Progress in Neurobiology·S C PrevitaliH Hartung
Jul 6, 2000·European Psychiatry : the Journal of the Association of European Psychiatrists·O SaarentoM Isohanni
Nov 7, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N PatelK M Shakesheff
Jan 17, 2003·Journal of Neuropathology and Experimental Neurology·Hu Liang LowLinda Greensmith
Jul 5, 2001·Journal of Neuroscience Research·S S SchererD H Gutmann
Aug 28, 2021·International Journal of Molecular Sciences·Cheng-Shyuan RauChing-Hua Hsieh

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