The dynamics of biomarkers across the clinical spectrum of Alzheimer's disease.

Alzheimer's Research & Therapy
Christoforos HadjichrysanthouAlzheimer’s Disease Neuroimaging Initiative

Abstract

Quantifying changes in the levels of biological and cognitive markers prior to the clinical presentation of Alzheimer's disease (AD) will provide a template for understanding the underlying aetiology of the clinical syndrome and, concomitantly, for improving early diagnosis, clinical trial recruitment and treatment assessment. This study aims to characterise continuous changes of such markers and determine their rate of change and temporal order throughout the AD continuum. The methodology is founded on the development of stochastic models to estimate the expected time to reach different clinical disease states, for different risk groups, and synchronise short-term individual biomarker data onto a disease progression timeline. Twenty-seven markers are considered, including a range of cognitive scores, cerebrospinal (CSF) and plasma fluid proteins, and brain structural and molecular imaging measures. Data from 2014 participants in the Alzheimer's Disease Neuroimaging Initiative database is utilised. The model suggests that detectable memory dysfunction could occur up to three decades prior to the onset of dementia due to AD (ADem). This is closely followed by changes in amyloid-β CSF levels and the first cognitive decline, as as...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
May 1, 1988·Annals of Neurology·L BergL A Coben
Nov 1, 1984·The American Journal of Psychiatry·W G RosenK L Davis
May 1, 1982·Journal of Gerontology·R I PfefferS Filos
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Sep 25, 2003·Lancet Neurology·Kaj Blennow, Harald Hampel
Mar 3, 2004·Annals of Neurology·William E KlunkBengt Långström
Apr 13, 2004·Lancet·Nick C Fox, Jonathan M Schott
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Aug 21, 2007·Brain : a Journal of Neurology·Norman L FosterSatoshi Minoshima
Dec 11, 2008·Annals of Neurology·Hélène AmievaJean François Dartigues
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Feb 27, 2010·Annals of Neurology·John C MorrisMark A Mintun
May 11, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·William J JagustUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 18, 2010·Neurobiology of Aging·Christopher C RoweVictor L Villemagne
Jan 20, 2011·JAMA : the Journal of the American Medical Association·Christopher M ClarkUNKNOWN AV45-A07 Study Group
Apr 26, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackCreighton H Phelps
Jun 15, 2011·Archives of Neurology·Raymond Y LoUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 23, 2011·Journal of Alzheimer's Disease : JAD·Eric YangUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 14, 2011·Alzheimer Disease and Associated Disorders·Emily Schoenhofen Sharp, Margaret Gatz
Aug 10, 2011·Archives of Neurology·Mert R SabuncuUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 13, 2012·The New England Journal of Medicine·Randall J BatemanUNKNOWN Dominantly Inherited Alzheimer Network
Sep 4, 2012·Neuropsychologia·Rebecca E AmariglioDorene M Rentz
Oct 31, 2012·Annals of Neurology·Susan M LandauUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 9, 2013·Nature Reviews. Neurology·Chia-Chen LiuGuojun Bu
Mar 13, 2013·Lancet Neurology·Victor L VillemagneUNKNOWN Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group
Apr 5, 2013·Alzheimer's Research & Therapy·Henrik ZetterbergOskar Hansson
Mar 7, 2014·Science Translational Medicine·Anne M FaganUNKNOWN Dominantly Inherited Alzheimer Network
Mar 25, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael C DonohueUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 23, 2014·Lancet Neurology·Bruno DuboisJeffrey L Cummings
Jun 3, 2014·JAMA Neurology·Michael C DonohueUNKNOWN Alzheimer’s Disease Cooperative Study
Jun 15, 2014·Neurology·Davis C RymanUNKNOWN Dominantly Inherited Alzheimer Network
Sep 12, 2015·Medical Image Analysis·Alexandra L YoungUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 3, 2015·JAMA Neurology·Henrik ZetterbergUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 25, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Jinping WangAndrew Satlin
May 31, 2016·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Erik StomrudOskar Hansson
Sep 21, 2016·Annals of Clinical and Translational Neurology·Luke W BonhamJennifer S Yokoyama
Mar 28, 2017·JAMA Neurology·Niklas MattssonUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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Citations

Jan 28, 2021·International Journal of Molecular Sciences·Samo Ribarič
Jan 13, 2021·Neural Regeneration Research·Zhefeng Guo
Jun 11, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Colin BirkenbihlUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 6, 2021·Journal of Alzheimer's Disease : JAD·David R ElmalehEran Segal
Aug 31, 2021·Molecular Psychiatry·Harald HampelAndrea Vergallo
Sep 29, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Dallas P VeitchUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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Software Mentioned

R2MLwiN package
MATLAB
R

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