PMID: 8939669DOI: 10.1016/s0955-0674(96)80076-7Dec 1, 1996Paper
The dynamics of cyclin dependent kinase structure
Current Opinion in Cell Biology
D O Morgan
Abstract
In the past year, several new crystal structures have provided exciting insights into the conformational changes underlying the regulation of cyclin-dependent kinases. We now understand the structural basis of many of the mechanisms by which cyclin-dependent kinases are regulated, including activation by cyclin binding and phosphorylation, inhibition by the inhibitor p27, and binding by the CKS proteins.
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