The dynamics of death in prostate cancer

American Journal of Clinical Pathology
Robin T Vollmer

Abstract

The hazard function provides the instantaneous probability of death (or other key end point) at various times after diagnosis. Unlike the survival curve, the hazard function illustrates graphically or through calculations when deaths are common or uncommon. In this study, hazard functions were derived for prostate cancer by using survival data on large numbers of patients with prostate cancer with data in the Surveillance, Epidemiology and End Results (SEER) database. The results demonstrate a form of prostate cancer that rapidly evolves to cause death within 5 years, and this form of tumor is only partly identified by routine prognostic variables such as serum prostate-specific antigen (PSA) level, histologic grade, and quantity of tumor. The results also validate the presence of a reservoir of nonfatal prostate cancers that have increased rapidly during the PSA era, and they demonstrate that the incidence of fatal prostate cancers has declined.

References

Aug 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G L Andriole
Oct 8, 1987·The New England Journal of Medicine·T A StameyE Redwine
Oct 1, 1989·The Journal of Urology·M A HudsonW J Catalona
Oct 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J Simes, M Zelen
Aug 1, 1970·Journal of Reproduction and Fertility·R J AblinE Witebsky
Jan 1, 1981·The Prostate·M C WangT M Chu
Jan 1, 1994·Journal of Clinical Epidemiology·M E CowenW F Weitzel
Jan 6, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S S Cross
Jul 4, 2002·Journal of the National Cancer Institute·Ruth EtzioniEric J Feuer
Jan 23, 2003·The Prostate·Joseph D KronzJonathan I Epstein
Jul 25, 2003·The New England Journal of Medicine·Rinaa S PungliaKaren M Kuntz
Oct 12, 2004·Biostatistics·Ori Davidov, Marvin Zelen
Jun 11, 2005·Human Pathology·Gregory A Hosler, Jonathan I Epstein
Dec 20, 2008·American Journal of Clinical Pathology·Robin T Vollmer
Mar 20, 2009·The New England Journal of Medicine·Gerald L AndrioleUNKNOWN PLCO Project Team
Mar 20, 2009·The New England Journal of Medicine·Fritz H SchröderUNKNOWN ERSPC Investigators
Sep 2, 2009·Journal of the National Cancer Institute·H Gilbert Welch, Peter C Albertsen
Apr 24, 2010·Journal of the National Cancer Institute·H Gilbert Welch, William C Black

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Citations

Oct 18, 2012·Journal of Cutaneous Pathology·Robin T Vollmer
Aug 1, 2016·European Urology·Scott P KellyMichael B Cook
Dec 18, 2013·American Journal of Clinical Pathology·Robin T Vollmer
Apr 10, 2014·American Journal of Clinical Pathology·Robin T Vollmer
Jan 4, 2017·Prostate Cancer and Prostatic Diseases·J J TosoianP C Walsh
May 31, 2019·Journal of Computational Chemistry·Emma L Cates, Tanja van Mourik
Apr 11, 2017·American Journal of Clinical Pathology·Robin T Vollmer
Nov 26, 2020·American Journal of Clinical Pathology·Robin Vollmer

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