PMID: 18209927Jan 23, 2008Paper

The dynamics of dengue virus serotype 3 introduction and dispersion in the state of Bahia, Brazil

Memórias do Instituto Oswaldo Cruz
Paulo Roberto Santana de MeloMitermayer Galvão dos Reis

Abstract

By 2002, dengue virus serotype 1 (DENV-1) and DENV-2 had circulated for more than a decade in Brazil. In 2002, the introduction of DENV-3 in the state of Bahia produced a massive epidemic and the first cases of dengue hemorrhagic fever. Based on the standardized frequency, timing and location of viral isolations by the state's Central Laboratory, DENV-3 probably entered Bahia through its capital, Salvador, and then rapidly disseminated to other cities, following the main roads. A linear regression model that included traffic flow, distance from the capital and DENV-1 circulation (r2 = 0.24, p = 0.001) supported this hypothesis. This pattern was not seen for serotypes already in circulation and was not seen for DENV-3 in the following year. Human population density was another important factor in the intensity of viral circulation. Neither DENV-1 nor DENV-2 fit this model for 2001 or 2003. Since the vector has limited flight range and vector densities fail to correlate with intensity of viral circulation, this distribution represents the movement of infected people and to some extent mosquitoes. This pattern may mimic person-to-person spread of a new infection.

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Citations

Jan 5, 2014·PLoS Neglected Tropical Diseases·Maria Glória TeixeiraGraham Joint
Jan 13, 2010·The American Journal of Tropical Medicine and Hygiene·José Luis San MartínMaría G Guzmán
Oct 9, 2012·The American Journal of Tropical Medicine and Hygiene·Olivia Brathwaite DickGustavo H Dayan
Dec 31, 2014·Interdisciplinary Perspectives on Infectious Diseases·Antonio Camargo MartinsMônica da Silva-Nunes
Sep 23, 2009·Journal of Medical Entomology·N A HonórioR Lourenço-De-Oliveira
Jun 9, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Veasna DuongPhilippe Buchy
Jul 16, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Veasna DuongPhilippe Buchy
Sep 15, 2012·Tropical Medicine & International Health : TM & IH·Maria G TeixeiraMaria da Conceição N Costa
Mar 17, 2009·Cadernos de saúde pública·Maria Glória TeixeiraMaurício Lima Barreto
Apr 8, 2021·Revista brasileira de epidemiologia = Brazilian journal of epidemiology·Juliana Maria Trindade BezerraDavid Soeiro Barbosa

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