The dynamics of functional connectivity in neocortical focal epilepsy

NeuroImage. Clinical
Mangor PedersenGraeme D Jackson

Abstract

Focal epilepsy is characterised by paroxysmal events, reflecting changes in underlying local brain networks. To capture brain network activity at the maximal temporal resolution of the acquired functional magnetic resonance imaging (fMRI) data, we have previously developed a novel analysis framework called Dynamic Regional Phase Synchrony (DRePS). DRePS measures instantaneous mean phase coherence within neighbourhoods of brain voxels. We use it here to examine how the dynamics of the functional connections of regional brain networks are altered in neocortical focal epilepsy. Using task-free fMRI data from 21 subjects with focal epilepsy and 21 healthy controls, we calculated the power spectral density of DRePS, which is a measure of signal variability in local connectivity estimates. Whole-brain averaged power spectral density of DRePS, or signal variability of local connectivity, was significantly higher in epilepsy subjects compared to healthy controls. Maximal increase in DRePS spectral power was seen in bilateral inferior frontal cortices, ipsilateral mid-cingulate gyrus, superior temporal gyrus, caudate head, and contralateral cerebellum. Our results provide further evidence of common brain abnormalities across people with...Continue Reading

Citations

May 28, 2019·Nature Reviews. Neuroscience·Martijn P van den Heuvel, Olaf Sporns
Mar 30, 2018·Frontiers in Neurology·Chuanzuo YangQingyun Wang
Dec 10, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Qian CuiHuafu Chen
May 24, 2021·Neurobiology of Disease·Mangor Pedersen, Andrew Zalesky
Jun 1, 2021·Frontiers in Neurology·William J BoslTobias Loddenkemper

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Software Mentioned

PSD DRePS
MATLAB
DRePS
DARTEL
SPM12

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