The dynamics of insight in the prodrome of schizophrenia

CNS Spectrums
Robert G BotaDaniela A Bota

Abstract

Schizophrenia is characterized by diminished insight, which fluctuates with disease progression. Insight deterioration in the prodrome of schizophrenia is poorly understood. Despite pharmacologic treatment, including early interventions, there is a high risk of relapse and need of acute care in schizophrenia patients. To study if insight deterioration occurs during the prodrome and if insight preservation early in the illness might predict a better prognosis. Data was collected retrospectively from the records of 24 patients initially diagnosed with schizophrenia during a 2-year period. Patients' progress was then tracked over a 3-year period. Insight was determined by a physician's subjective evaluation, patient interest and participation in treatment planning, and patient accuracy in reporting behaviors and symptoms when compared with reports from collaterals. Ten patients were determined to have insight regarding the developing illness at different presentations at the hospital. Insight preservation correlated with less need for emergency visits and fewer hospitalization days (P<.005). It was also associated with more depressive and anxious mood (P<.000). Patients and family members described early, ego-dystonic perceptual d...Continue Reading

References

Sep 1, 1992·The American Journal of Psychiatry·A D LoebelS R Szymanski
Jan 1, 1991·Schizophrenia Bulletin·R J Wyatt
Oct 1, 1989·Archives of General Psychiatry·P E Meehl
Jan 1, 1989·Psychopathology·H EbelG Huber
Mar 1, 1985·The Journal of Nervous and Mental Disease·D W HeinrichsW T Carpenter
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jun 1, 1973·Psychological Reports·A Flemenbaum, R L Zimmermann
Sep 23, 1995·Lancet·J M Kane, T H McGlashan
Oct 1, 1994·Archives of General Psychiatry·X F AmadorJ M Gorman
Jun 1, 1993·The American Journal of Psychiatry·X F AmadorJ M Gorman
Jan 1, 1996·Schizophrenia Bulletin·T K LarsenL C Moe
Jan 1, 1996·Schizophrenia Bulletin·A R YungA Rakkar
Jan 1, 1996·Schizophrenia Bulletin·P D McGorryH J Jackson
Oct 1, 1996·The Australian and New Zealand Journal of Psychiatry·A R Yung, P D McGorry
Jan 1, 1997·The Psychiatric Quarterly·J M Harkavy-Friedman, E A Nelson
Feb 7, 2001·Schizophrenia Bulletin·T E SmithD F Willson
Feb 24, 2001·Journal of the American Psychoanalytic Association·P Fonagy
Feb 21, 2002·Schizophrenia Research·Barbara CornblattMichael Obuchowski
Mar 5, 2002·Psychiatric Services : a Journal of the American Psychiatric Association·Adrian PredaScott W Woods
Mar 29, 2002·Psychiatric Services : a Journal of the American Psychiatric Association·Ashok K MallaDerek J Scholten
Apr 13, 2002·Schizophrenia Research·Ashok K MallaJatinder Takhar
Aug 13, 2002·Psychiatric Rehabilitation Journal·Nicolas Rüsch, Patrick W Corrigan
Dec 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eugenio AgugliaDomenico Ferrara
Dec 31, 2002·Schizophrenia Research·Chan-Hyung KimHerbert Y Meltzer
Jan 23, 2003·Psychological Medicine·S M HarriganH Krstev
Mar 22, 2003·Schizophrenia Research·Alisa R MintzDavid M Romney
Jul 18, 2003·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Luca ArduiniAlessandro Rossi
Jul 18, 2003·The Journal of the American Academy of Psychoanalysis and Dynamic Psychiatry·Ann-Louise S Silver
Aug 1, 1964·Archives of General Psychiatry·D B PETERSON, G W OLSON
Nov 13, 2003·Epidemiologia e psichiatria sociale·Ayana A Gibbs, Anthony S David
Dec 13, 2003·Comprehensive Psychiatry·Serge SevyXavier Amador
Feb 6, 2004·Journal of Psychiatric Research·Thomas E SmithJoel F McClough
Feb 26, 2004·Psychological Medicine·R J DrakeS W Lewis
Jun 29, 2004·NeuroImage·Mujeeb U ShadMatcheri S Keshavan
Aug 27, 2004·Schizophrenia Research·Matcheri S KeshavanNina Schooler
Sep 3, 2004·Bulletin of the Menninger Clinic·Lisa Lewis
Sep 7, 2004·The Journal of Nervous and Mental Disease·Gary DonohoeEadbhard O'Callaghan
Apr 22, 2005·Bulletin of the Menninger Clinic·Maurizio PompiliRoberto Tatarelli

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Citations

Feb 1, 2008·Early Intervention in Psychiatry·Constantin TranulisAshok Malla
Jul 11, 2009·Expert Review of Neurotherapeutics·Paul H LysakerGiancarlo Dimaggio
Dec 23, 2017·Early Intervention in Psychiatry·Sunny Chieh ChengEleanor Chen
Nov 8, 2008·Bulletin of the Menninger Clinic·Robert G BotaStuart Munro
Apr 8, 2016·International Journal of Psychiatry in Clinical Practice·Stefano PorcelliAlessandro Serretti
Feb 8, 2008·Bulletin of the Menninger Clinic·Robert G Bota, Walter F Ricci
Jul 25, 2014·International Journal of Geriatric Psychiatry·Philip GerretsenAriel Graff-Guerrero
Oct 3, 2007·Journal of Psychosocial Nursing and Mental Health Services·Paul H Lysaker, Kelly D Buck

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