PMID: 9178257Apr 1, 1997Paper

The dynamics of neurogenic signalling underlying bristle development in Drosophila melanogaster

Mechanisms of Development
A L ParksM A Muskavitch

Abstract

We have examined expression of the neurogenic gene, Delta (Dl), and the regulatory relationships between the Delta-Notch signalling pathway and the proneural gene, achaete, during microchaeta development in Drosophila. Delta is expressed in all microchaeta proneural cells and microchaeta sensory organ precursors (SOPs) and is expressed dynamically in SOP progeny. We find that Delta expression in microchaeta proneural cells is detected prior to the onset of achaete expression and arises normally in the absence of achaete/scute function, indicating that initial Delta expression in the notum is not dependent on proneural gene function. Activation of the Delta-Notch pathway results in loss of Delta protein accumulation, suggesting that Delta expression is regulated, in part, by Delta-Notch signalling activity. We find that Delta signalling is required for correct delineation of early proneural gene expression in developing nota. Within microchaeta proneural stripes, we demonstrate that Delta-Notch signalling prohibits adoption of the SOP fate by repressing expression of proneural genes.

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Citations

Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N E Baker
Aug 1, 1997·Current Opinion in Genetics & Development·P Simpson
Aug 22, 2007·Trends in Cell Biology·R J FlemingS Artavanis-Tsakonas
Sep 2, 2008·Oncogene·B D'SouzaG Weinmaster
Apr 23, 2010·Molecular Biology of the Cell·Najate BenhraRoland Le Borgne
Feb 19, 2005·BMC Developmental Biology·Virginie Orgogozo, Wesley B Grueber
Jul 3, 2008·BMC Developmental Biology·Serene Keilani, Kiminobu Sugaya
May 4, 2007·Neural Development·Natalia Sánchez-SorianoAndreas Prokop
Oct 18, 2008·Development·Hao TangBlanche Capel
Sep 3, 2011·PloS One·Kaveh DaneshvarJulie M Goodliffe
May 2, 2014·PloS One·Pau Formosa-Jordan, Marta Ibañes
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M EddisonJ Lewis
Dec 4, 2010·European Journal of Cell Biology·Ralf SchwanbeckUrsula Just
Apr 30, 2008·Genesis : the Journal of Genetics and Development·Annette L ParksMarc A T Muskavitch
Aug 4, 2004·Seminars in Cancer Biology·Brendan J CollinsDouglas W Ball
Feb 1, 2011·Current Biology : CB·Akiko KotoMasayuki Miura
Jun 23, 2011·PLoS Computational Biology·David SprinzakMichael B Elowitz

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