PMID: 11920530Mar 29, 2002Paper

The dynamics of prostate specific antigen during watchful waiting of prostate carcinoma: a study of 94 Japanese men

Cancer
Robin T VollmerShiro Baba

Abstract

For the moment, there is uncertainty about the usefulness of early treatment of localized prostate carcinoma, uncertainty about whether some patients with early cancer can be managed expectantly, and uncertainty about how such patients might be recognized. The authors studied serial values of prostate specific antigen (PSA) in 94 Japanese men with diagnosed prostate carcinoma and who were managed by watchful waiting. Their median follow-up duration was 32 months (range, 1.6-118). The authors used a log-linear model to fit the values of PSA over time, and then they used the Cox survival model to relate the intercept (PSA amplitude) and slope (relative velocity) to observed local or systemic outcomes that were independent of PSA. The authors found that the log-linear model fit the serial values of PSA during watchful waiting very well. Prostate specific antigen amplitude related significantly to T classification (P = 0.0006), but not to grade (P > 0.2), and the relative velocity related significantly to both T classification (P = 0.009) and to grade (P = 0.02). Although the T classification, histologic grade, and log(PSA) at diagnosis were associated significantly with time to outcome, the combination of amplitude and relative ve...Continue Reading

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Citations

Apr 5, 2007·Journal of the National Cancer Institute·Katja FallUNKNOWN Scandinavian Prostate Cancer Group Study No. 4
Mar 11, 2004·Journal of General Internal Medicine·Vickie L ShaversAngela Fahey
Dec 27, 2011·Pathology·Ken Sikaris
Jan 23, 2010·American Journal of Clinical Pathology·Robin T Vollmer
Jan 29, 2008·The Journal of Urology·Shomik SenguptaMichael L Blute
Nov 13, 2007·The Journal of Urology·David RobinsonUNKNOWN Scandinavian Prostate Cancer Group (SPCG)-5
Oct 30, 2009·BJU International·Matthew K TollefsonR Jeffrey Karnes
Nov 25, 2003·The Journal of Urology·Maxwell V MengPeter R Carroll
Mar 17, 2004·The Journal of Urology·Manish I PatelPeter T Scardino
Feb 8, 2006·Urology·Shomik SenguptaEric J Bergstralh
Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Mark K BuyyounouskiAlan Pollack
Jun 14, 2012·Postgraduate Medicine·David L PanMurugesan Manoharan
Nov 8, 2020·Bulletin of Mathematical Biology·Raegan HigginsAngela Peace

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