The dynamics of the metabolism of acetate and bicarbonate associated with use of hemodialysates in the ABChD trial: a phase IV, prospective, single center, single blind, randomized, cross-over, two week investigation

BMC Nephrology
William B SmithFranklin W Maddux

Abstract

In the United States, hemodialysis (HD) is generally performed via a bicarbonate dialysate. It is not known if small amounts of acid used in dialysate to buffer the bicarbonate can meaningfully contribute to overall buffering administered during HD. We aimed to investigate the metabolism of acetate with use of two different acid buffer concentrates and determine if it effects blood bicarbonate concentrations in HD patients. The Acid-Base Composition with use of hemoDialysates (ABChD) trial was a Phase IV, prospective, single blind, randomized, cross-over, 2 week investigation of peridialytic dynamics of acetate and bicarbonate associated with use of acid buffer concentrates. Eleven prevalent HD patients participated from November 2014 to February 2015. Patients received two HD treatments, with NaturaLyte® and GranuFlo® acid concentrates containing 4 and 8 mEq/L of acetate, respectively. Dialysate order was chosen in a random fashion. The endpoint was to characterize the dynamics of acetate received and metabolized during hemodialysis, and how it effects overall bicarbonate concentrations in the blood and dialysate. Acetate and bicarbonate concentrations were assessed before, at 8 time points during, and 6 time points after the ...Continue Reading

Associated Clinical Trials

References

Feb 15, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Kveim, J E Bredesen
Sep 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jürgen BommerEric W Young
Jun 16, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jeffrey A Kraut, Ira Kurtz
Feb 9, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco PizzarelliGiuseppe Ferro
Jul 7, 2007·The AAPS Journal·Marian Kelley, Binodh DeSilva
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Dennis Y WuKamyar Kalantar-Zadeh
Jan 27, 2009·Blood Purification·Nicholas A HoenichClaudio Ronco
Jan 12, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Antonio Alberto LopesFriedrich K Port
Jul 6, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Piergiorgio BolascoSardinian Polycentric Study on Acetate-Free Haemodiafiltration
Apr 17, 2012·The International Journal of Artificial Organs·Hélène MorelCécile Legallais
May 28, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Francesca TentoriFriedrich K Port
Sep 27, 2014·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Juan J Sánchez-CanelRamón Pons-Prades
May 28, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tadashi YamamotoYoshiharu Tsubakihara
Jul 15, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Madhukar Misra
Jul 15, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Philippe ChauveauChristian Combe

Citations

Apr 3, 2019·Seminars in Dialysis·Jaime Uribarri, Man S Oh

Methods Mentioned

BETA
pregnancy test
blood collection
blood draws

Clinical Trials Mentioned

NCT02334267

Related Concepts

Acetic Acids
Anion Gap
Carbonic Acid Ions
Hemodialysis
Kidney Failure, Chronic
Hemodialyzates
Single-Masked Study
Cross-Over Studies
Acetate
Acids

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.