The dynamics of the RNA world: insights and challenges.

Annals of the New York Academy of Sciences
Ádám KunEörs Szathmáry

Abstract

The RNA world hypothesis of the origin of life, in which RNA emerged as both enzyme and information carrier, is receiving solid experimental support. The prebiotic synthesis of biomolecules, the catalytic aid offered by mineral surfaces, and the vast enzymatic repertoire of ribozymes are only pieces of the origin of life puzzle; the full picture can only emerge if the pieces fit together by either following from one another or coexisting with each other. Here, we review the theory of the origin, maintenance, and enhancement of the RNA world as an evolving population of dynamical systems. The dynamical view of the origin of life allows us to pinpoint the missing and the not fitting pieces: (1) How can the first self-replicating ribozyme emerge in the absence of template-directed information replication? (2) How can nucleotide replicators avoid competitive exclusion despite utilizing the very same resources (nucleobases)? (3) How can the information catastrophe be avoided? (4) How can enough genes integrate into a cohesive system in order to transition to a cellular stage? (5) How can the way information is stored and metabolic complexity coevolve to pave to road leading out of the RNA world to the present protein-DNA world?

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Citations

Feb 16, 2016·Journal of Theoretical Biology·András G Hubai, Ádám Kun
Aug 27, 2015·Life·Ádám Kun, Eörs Szathmáry
Feb 6, 2016·Endocrine Pathology·Ranran ZhangRicardo V Lloyd
Apr 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Eörs Szathmáry
Nov 15, 2017·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·N TakeuchiK Kaneko
Jan 9, 2020·PLoS Computational Biology·Yong Chen, Wentao Ma
Dec 13, 2016·Science·Shigeyoshi MatsumuraAndrew D Griffiths
Jul 22, 2018·PLoS Computational Biology·Ximo PechuanAviv Bergman
Apr 17, 2019·Life·Stefano PiottoSimona Concilio
Sep 23, 2018·Biology Direct·Marc Tessera
Feb 13, 2016·Annual Review of Plant Biology·Lee E VandivierBrian D Gregory
Nov 25, 2018·Journal of Theoretical Biology·Zsuzsanna Vig-MilkovicsEörs Szathmáry
Jan 27, 2021·PLoS Computational Biology·Dániel VörösTamás Czárán
Nov 27, 2020·IScience·Cyrille JeancolasPhilippe Nghe
Mar 31, 2021·Annual Review of Biochemistry·Charles W Carter, Peter R Wills
Jul 13, 2021·AIMS Microbiology·Luis P Villarreal, Guenther Witzany

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