Atherosclerosis is the most frequent complication of diabetes. There are many potentially atherogenic factors in diabetes that may underlie this problem. Of these, one is the group of dyslipoproteinemias. In diabetes there are both qualitative and quantitative changes in the plasma lipoproteins. Based on pathophysiological and epidemiological data, these may be among the many factors that can result in early macrovascular disease. Furthermore, at least one of the dyslipoproteinemias--hypertriglyceridemia--is associated with insulin resistance and therefore could aggravate glucose intolerance. Thus, on theoretical grounds it is reasonable to postulate that treating the dyslipoproteinemias of diabetes would reduce atherosclerotic disease. However, to date there have been no intervention studies specifically designed to test this postulate in the diabetic population. One such study, the Diabetes Atherosclerosis Intervention Study, is currently in progress.
Serum lipids and lipoproteins in insulin-treated diabetes. Demonstration of increased high density lipoprotein concentrations
Effects of continuous insulin infusion therapy on lipoprotein surface and core lipid composition in insulin-dependent diabetes mellitus
The association of increased levels of intermediate-density lipoproteins with smoking and with coronary artery disease
Relative contribution of triglyceride-rich lipoprotein particle size and number to plasma triglyceride concentration
Comparison of glucosylated low density lipoprotein with methylated or cyclohexanedione-treated low density lipoprotein in the measurement of receptor-independent low density lipoprotein catabolism
Plasma and lipoprotein cholesterol and triglyceride in the Pima Indian population. Comparison of diabetics and nondiabetics
Decreased plasma phosphatidylcholine/free cholesterol ratio as an indicator of risk for ischemic vascular disease
The metabolism of very low density and intermediate density lipoproteins in patients with familial hypercholesterolaemia
Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial
Important contribution of lipoprotein particle number to plasma triglyceride concentration in type 2 diabetes
Ca2+ regulatory mechanisms of exercise protection against coronary artery disease in metabolic syndrome and diabetes
Effects of diabetes and CETP expression on diet-induced atherosclerosis in LDL receptor-deficient mice
Baseline characteristics of the study population in the Diabetes Atherosclerosis Intervention Study (DAIS). World Health Organization Collaborating Centre for the Study of Atherosclerosis in Diabetes
Increased atherosclerosis in diabetic dyslipidemic swine: protection by atorvastatin involves decreased VLDL triglycerides but minimal effects on the lipoprotein profile.
Autoantibodies to glutamic acid decarboxylase in diabetic patients from a multi-ethnic Australian community: the Fremantle Diabetes Study
The severity of coronary atherosclerosis in type 2 diabetes mellitus is related to the number of circulating triglyceride-rich lipoprotein particles
Assessment of Subtle Changes in Diabetes-Associated Arteriosclerosis using Photoplethysmographic Pulse Wave from Index Finger
Early Signs of Atherogenic Features in the HDL Lipidomes of Normolipidemic Patients Newly Diagnosed with Type 2 Diabetes.
ApoE, Lipids & Cholesterol
Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.
Carotid Artery Diseases
Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.