The DYW-subgroup pentatricopeptide repeat protein PPR27 interacts with ZmMORF1 to facilitate mitochondrial RNA editing and seed development in maize.

Journal of Experimental Botany
Rui LiuBao-Cai Tan

Abstract

C-to-U RNA editing in plant mitochondria requires the participation of many nucleus-encoded factors, most of which are pentatricopeptide repeat (PPR) proteins. There is a large number of PPR proteins and the functions many of them are unknown. Here, we report a mitochondrion-localized DYW-subgroup PPR protein, PPR27, which functions in the editing of multiple mitochondrial transcripts in maize. The ppr27 mutant is completely deficient in C-to-U editing at the ccmFN-1357 and rps3-707 sites, and editing at six other sites is substantially reduced. The lack of editing at ccmFN-1357 causes a deficiency of CcmFN protein. As CcmFN functions in the maturation pathway of cytochrome proteins that are subunits of mitochondrial complex III, its deficiency results in an absence of cytochrome c1 and cytochrome c proteins. Consequently, the assembly of mitochondrial complex III and super-complex I+III2 is decreased, which impairs the electron transport chain and respiration, leading to arrests in embryogenesis and endosperm development in ppr27. In addition, PPR27 was found to physically interact with ZmMORF1, which interacts with ZmMORF8, suggesting that these three proteins may facilitate C-to-U RNA editing via the formation of a complex i...Continue Reading

References

May 1, 1993·Molecular & General Genetics : MGG·W SchusterA Brennicke
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·P Giegé, A Brennicke
Nov 13, 2002·The Journal of Biological Chemistry·Patrice P HamelSabeeha Merchant
Dec 7, 2002·The Plant Cell·Olga V KarpovaKathleen J Newton
Apr 4, 2003·Analytical Biochemistry·Robert FeissnerRobert G Kranz
Nov 24, 2007·Mitochondrion·P GiegéG Bonnard
Nov 14, 2008·Trends in Plant Science·Christian Schmitz-Linneweber, Ian Small
Apr 13, 2010·Trends in Microbiology·Carsten SandersFevzi Daldal
Oct 22, 2010·Nature·Nick Lane, William Martin
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mizuki TakenakaAxel Brennicke
May 1, 2012·The Plant Journal : for Cell and Molecular Biology·Qiang ZhuDominique Van Der Straeten
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Stephane BentolilaMaureen R Hanson
Jul 4, 2012·The Plant Journal : for Cell and Molecular Biology·Takushi TodaKinya Toriyama
Mar 5, 2013·The Plant Journal : for Cell and Molecular Biology·Yun ShenBao-Cai Tan
Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tao SunStéphane Bentolila
Jan 17, 2014·Nature·Jonathan R Friedman, Jodi Nunnari
Jan 28, 2014·Trends in Plant Science·Kamel Hammani, Philippe Giegé
Jan 30, 2014·Annual Review of Plant Biology·Alice Barkan, Ian Small
Mar 7, 2014·Frontiers in Plant Science·Gregory G BrownOren Ostersetzer-Biran
Jan 23, 2015·Nucleic Acids Research·Benjamin S GullyCharles S Bond
Mar 25, 2015·Nucleic Acids Research·Xiaowen ShiStéphane Bentolila
Jan 15, 2016·The Plant Journal : for Cell and Molecular Biology·Zhihui XiuBao-Cai Tan
Jan 15, 2016·Current Biology : CB·Daniel B Sloan, Zhiqiang Wu
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
Sep 23, 2016·Nature·James A LettsLeonid A Sazanov
Dec 28, 2016·Genes·Mizuho Ichinose, Mamoru Sugita
Feb 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Wen ZhouCongming Lu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.