The E-cadherin (CDH1) -C160A polymorphism and colorectal cancer susceptibility: a meta-analysis

DNA and Cell Biology
Peiliang GengHoujie Liang

Abstract

E-cadherin, encoded by the CDH1 gene, involves in invasion and metastasis of cancer cells. CDH1 -C160A polymorphism was shown to contribute to genetic susceptibility to colorectal cancer (CRC). However, the results from different studies remain controversial. This study was conducted to further explore the association between CDH1 -C160A genetic polymorphism and CRC susceptibility by means of a meta-analysis. A comprehensive literature search was conducted to identify all case-control studies of CDH1 -C160A polymorphism and risk for CRC. A total of nine eligible studies, including 7954 CRC cases and 7369 controls, were identified to the meta-analysis. On the whole, the meta-analysis indicated that CDH1 -C160A genetic polymorphism could reduce the risk of CRC under AA versus CC contrast (odds ratio [OR]=0.86, 95% confidence interval [CI]=0.75-0.98, p(heterogeneity)=0.11), recessive model (OR=0.88, 95% CI=0.77-0.99, p(heterogeneity)=0.23), dominant model (OR=0.92, 95% CI=0.87-0.99, p(heterogeneity)=0.11), and allele A versus allele C contrast (OR=0.93, 95% CI=0.88-0.98, p(heterogeneity)=0.26). A conclusion could be drawn from the research that CDH1 -C160A polymorphism provides a possible protection against CRC, which is especiall...Continue Reading

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Citations

May 25, 2012·Genetic Testing and Molecular Biomarkers·Lin LinJin Liu
Apr 5, 2013·Genetic Testing and Molecular Biomarkers·Nageswara Rao TipirisettiVishnupriya Satti
Aug 26, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Suresh GovatatiVaradacharyulu Nallanchakravarthula
Jun 29, 2016·World Journal of Surgical Oncology·Ying-Yu MaDong-Sheng Huang
Oct 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Wang JuanLi Yan
Nov 1, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Wang JuanLi Yan

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