The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development

Immunity
Masaki MiyazakiC Murre

Abstract

Innate and adaptive lymphoid development is orchestrated by the activities of E proteins and their antagonist Id proteins, but how these factors regulate early T cell progenitor (ETP) and innate lymphoid cell (ILC) development remains unclear. Using multiple genetic strategies, we demonstrated that E proteins E2A and HEB acted in synergy in the thymus to establish T cell identity and to suppress the aberrant development of ILCs, including ILC2s and lymphoid-tissue-inducer-like cells. E2A and HEB orchestrated T cell fate and suppressed the ILC transcription signature by activating the expression of genes associated with Notch receptors, T cell receptor (TCR) assembly, and TCR-mediated signaling. E2A and HEB acted in ETPs to establish and maintain a T-cell-lineage-specific enhancer repertoire, including regulatory elements associated with the Notch1, Rag1, and Rag2 loci. On the basis of these and previous observations, we propose that the E-Id protein axis specifies innate and adaptive lymphoid cell fate.

Citations

Dec 5, 2017·Frontiers in Immunology·Qiutong HuangGabrielle T Belz
Jun 1, 2018·European Journal of Immunology·Rhys JonesDavid R Withers
Oct 31, 2018·Nature Immunology·Hiroyuki HosokawaEllen V Rothenberg
Jan 22, 2019·Mucosal Immunology·Malcolm R StarkeyPhilip M Hansbro
Mar 23, 2019·The Journal of Experimental Medicine·Liangyue QianXiao-Hong Sun
Dec 13, 2019·The Journal of Experimental Medicine·Christelle Harly, Avinash Bhandoola
Feb 27, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mattia LionMarjorie A Oettinger
Mar 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Yong SongAsgerally T Fazleabas
May 8, 2018·The Journal of Experimental Medicine·Satoshi KogaKazuyo Moro
Dec 14, 2018·The Journal of Experimental Medicine·Abani Kanta NaikMichael S Krangel
Sep 5, 2019·Genes & Development·Ellen V Rothenberg
Oct 9, 2018·Immunological Reviews·Francisca F AlmeidaGabrielle T Belz
Jan 11, 2020·Frontiers in Immunology·Abdalla Sheikh, Ninan Abraham
Sep 13, 2020·Nature Reviews. Immunology·Hiroyuki Hosokawa, Ellen V Rothenberg
Jan 23, 2021·Proceedings of the National Academy of Sciences of the United States of America·Boyoung ShinEllen V Rothenberg
Feb 4, 2021·Cell Reports·Shawn P FahlDavid L Wiest
Jan 13, 2021·Nature Immunology·Ana C F FerreiraAndrew N J McKenzie
Feb 25, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hiroyuki HosokawaMaria Koizumi
May 28, 2019·Current Opinion in Immunology·Nicholas A SpidaleJoonsoo Kang
Oct 16, 2020·Immunological Reviews·Michele K Anderson, Johanna S Selvaratnam
Apr 17, 2021·Trends in Immunology·Laura BelverAdolfo A Ferrando
Jun 3, 2021·International Journal of Molecular Sciences·Genki YoshikawaMasaki Miyazaki
May 25, 2021·Frontiers in Immunology·Samuel B Shin, Kelly M McNagny
Dec 4, 2021·Science Advances·Yi Zhou, Cornelis Murre

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.