PMID: 15240700Jul 9, 2004Paper

The E2F-1 transcription factor promotes caspase-8 and bid expression, and enhances Fas signaling in T cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Qingyu CaoI Nicholas Crispe

Abstract

The immune system depends on the extensive proliferation of rare Ag-specific precursor T lymphocytes, followed by their differentiation, the delivery of effector function, and finally death by apoptosis. T cells that lack the E2F-1 transcription factor, which is activated as cells pass the restriction point and enter S phase, show defects in activation-induced cell death. We now report that E2F-1 increases the activity of an apoptotic pathway that is important in murine primary T cells. Thus, E2F-1 promotes the transcription of Bid, a molecule that links death receptor signaling to the activation of apoptotic mechanisms in mitochondria. It also promotes the transcription of caspase-8, the enzyme that cleaves and activates Bid. Enforced expression of Bid can partially restore apoptosis in E2F-1-deficient T cells. Thus, E2F-1 integrates cell cycle progression with apoptosis.

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Citations

Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·William L RedmondLinda A Sherman
Sep 28, 2013·Rheumatology International·Xin-Yu Fang, Dong-Qing Ye
May 10, 2007·Journal of Cellular and Molecular Medicine·B M Pützer
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Jan 24, 2007·Physiological Reviews·Guido KroemerCatherine Brenner

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