The E2F5 repressor is an activator of E6/E7 transcription and of the S-phase entry in HPV18-associated cells

Oncogene
Sébastien TeissierFrançoise Thierry

Abstract

High-risk papillomavirus type 18 (HPV18) is one of the less represented HPV types in low-grade lesions of the anogenital tract, whereas it occupies the second place in cervical cancer, where it can be found in 16% of the cases worldwide, after HPV16 present in 54% of them. These epidemiological data indicate that HPV18 infection is more prone to carcinogenic progression. The main oncogenic proteins, E6 and E7 of HPV18, are functionally comparable to the homologous proteins of the other high-risk viruses, including HPV16. In this work, we investigated the possibility that the higher oncogenic potential of HPV18 might be due to transcriptional regulation of the E6/E7 oncogenes. By comparing the E6/E7 promoter and enhancer sequences of the mucosal HPV genomes, we identified E2F binding sites specific for HPV18. The E2F family of transcription factors contains activators (E2F1-3) and repressors (E2F4-8) that regulate the transcription of S-phase and mitotic genes and thereby have a crucial role in cell-cycle progression. Surprisingly, we identified E2F5 as a direct activator of HPV18 E6/E7 transcription by sequential silencing of E2F members in HeLa cells. In addition, we could show that E2F5 positively regulates S-phase entry in H...Continue Reading

References

Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·C SardetR A Weinberg
Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Jan 19, 2002·Genes & Development·Bing RenBrian David Dynlacht
Jun 29, 2002·The Journal of Biological Chemistry·Margarita D ApostolovaLina Dagnino
Oct 23, 2002·The Journal of Experimental Medicine·Edgar GrinsteinHans-Dieter Royer
Nov 26, 2002·The Journal of Biological Chemistry·Shirley Polager, Doron Ginsberg
Mar 18, 2003·Molecular and Cellular Biology·Isabelle BouallagaFrançoise Thierry
Feb 12, 2004·Cancer Research·Françoise ThierryChristian Desaintes
Oct 29, 2004·The EMBO Journal·Wencheng ZhuJoseph R Nevins
Dec 31, 2005·Proceedings of the National Academy of Sciences of the United States of America·Benyue ZhangAnn Roman
Aug 16, 2006·Oncogene·L-J KongJ R Nevins
Feb 14, 2007·Journal of Cellular Biochemistry·Sarah A ReedSally E Johnson
Mar 8, 2007·British Journal of Cancer·N W J BulkmansUNKNOWN POBASCAM Study Group
Mar 28, 2007·Journal of Cellular Physiology·Valentina CaraccioloPier Paolo Claudio
Jun 26, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ruprecht KunerFelix Hoppe-Seyler
Jun 27, 2008·Journal of Virology·Margaret E McLaughlin-DrubinKarl Münger

❮ Previous
Next ❯

Citations

Dec 4, 2012·Assay and Drug Development Technologies·Bhavneet BhinderHakim Djaballah
Jan 30, 2013·Journal of Cellular Physiology·Riccardo Di FioreRenza Vento
Jul 26, 2011·Cellular & Molecular Biology Letters·Mandy S Y LungVincent Murray
Aug 21, 2013·Virology·Eric Johannsen, Paul F Lambert
Nov 18, 2008·Hematology/oncology Clinics of North America·Laura Vidal, Maura L Gillison
Jun 3, 2021·International Journal of Molecular Sciences·Thu-Huyen PhamDo-Young Yoon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.