The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins

FEBS Letters
Julie BayleP De Sepulveda

Abstract

The suppressor of cytokine signaling (SOCS) proteins are thought to exert their function through the recruitment of interacting-proteins to the ubiquitin/proteasome degradation pathway. All SOCS proteins bind an Elongin BC E3 ubiquitin ligase complex through the common Socs-box. Here, we show that haem-oxidized IRP2 ubiquitin ligase-1 (HOIL-1), another E3 ubiquitin ligase, interacts with SOCS6. The Ubl domain of HOIL-1 and the SH2 and Socs-box domains of SOCS6 are required for the interaction. HOIL-1 expression stabilizes SOCS6 and induces the ubiquitination and degradation of proteins associated with SOCS6. These data suggest that SOCS proteins may interact with different E3 ubiquitin ligases in addition to a common Elongin BC E3 complex.

References

Jun 27, 1997·The Journal of Biological Chemistry·Y S CongE Seto
Nov 5, 1997·Biochemical and Biophysical Research Communications·M MasuharaA Yoshimura
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·M NarazakiT Kishimoto
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·J G ZhangM Baca
Sep 22, 1999·European Journal of Biochemistry·E SiewertF Schaper
Apr 5, 2000·The Journal of Biological Chemistry·P De SepulvedaR Rottapel
May 24, 2000·The Journal of Biological Chemistry·B EmanuelliE Van Obberghen
Jul 13, 2000·Nature·D MetcalfW S Alexander
Mar 30, 2001·The Journal of Biological Chemistry·S KamizonoA Yoshimura
Jun 8, 2002·Molecular and Cellular Biology·Danielle L KrebsWarren S Alexander
Jun 22, 2002·Trends in Biochemical Sciences·Benjamin T KileDouglas J Hilton
Aug 7, 2002·The Journal of Biological Chemistry·Elena ToniatoPaul Rothman
Sep 14, 2002·The Journal of Biological Chemistry·Liangyou RuiMorris F White
Mar 12, 2003·Nature Cell Biology·Koji YamanakaKazuhiro Iwai
Jun 5, 2003·The Journal of Biological Chemistry·Serge HaanNicholas A Cacalano
Oct 1, 2003·The EMBO Journal·Enbo LiuKristiina Vuori
Jan 7, 2004·The Journal of Biological Chemistry·Julie BaylePaulo De Sepulveda
Mar 23, 2004·Annual Review of Immunology·Warren S Alexander, Douglas J Hilton
Nov 16, 2004·Seminars in Immunology·Subburaj IlangumaranRobert Rottapel
Dec 14, 2004·The Journal of Biological Chemistry·Edith KarioYosef Yarden
Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sandra E NicholsonNicos A Nicola
Aug 17, 2005·Advances in Immunology·Tetsuji NakaAkihiko Yoshimura

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Citations

Dec 17, 2009·The Journal of Biological Chemistry·Young Bong ChoiYungdae Yun
Mar 1, 2012·Science Signaling·Christoph H EmmerichHenning Walczak
Jul 25, 2007·Blood·Jurgen A F MarteijnBert A Van der Reijden
Aug 31, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Nuzhat N KabirJulhash U Kazi
May 27, 2010·Cellular and Molecular Life Sciences : CMLS·Jérémie Gautheron, Gilles Courtois
Nov 3, 2009·Trends in Immunology·Douglas C Palmer, Nicholas P Restifo
Oct 25, 2008·Cytokine & Growth Factor Reviews·Julie PiessevauxJan Tavernier
Jul 3, 2007·Biochemical and Biophysical Research Communications·Mi-Na HwangSungpil Yoon
Jan 30, 2007·The Journal of Allergy and Clinical Immunology·Judit Knisz, Paul B Rothman
Sep 29, 2006·The EMBO Journal·Takayoshi KirisakoKazuhiro Iwai
Apr 21, 2012·Protein Science : a Publication of the Protein Society·Steven A BeasleyGary S Shaw
Jan 11, 2007·Biochemical and Biophysical Research Communications·Mi-Na HwangSungpil Yoon
Mar 1, 2014·The Biochemical Journal·Donald E SprattGary S Shaw
Sep 8, 2007·Biochimica Et Biophysica Acta·Kimberly B ZumbrennenElizabeth A Leibold
Jul 29, 2006·Biochimica Et Biophysica Acta·Michelle L WallanderRichard S Eisenstein
Feb 2, 2010·Biochemical and Biophysical Research Communications·Edwige VoissetPaulo De Sepulveda
Oct 18, 2012·Physiological Reviews·Johan Lennartsson, Lars Rönnstrand
Nov 19, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Julia StrebovskyAlexander H Dalpke
Feb 16, 2016·Regenerative Medicine·Yi FengWen G Jiang

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