PMID: 2110921Feb 1, 1990Paper

The E75 ecdysone-inducible gene responsible for the 75B early puff in Drosophila encodes two new members of the steroid receptor superfamily

Genes & Development
W Segraves, D S Hogness

Abstract

A pulse of the steroid hormone ecdysone at the end of Drosophila larval development triggers coordinate changes in both larval and imaginal tissues that result in metamorphosis to the adult fly. In larval salivary glands, this pulse activates a genetic regulatory hierarchy manifested by the induction of two kinds of transcription puffs in the polytene chromosomes: a small set of "early" puffs representing a primary response to the hormone, and a complex set of "late" puffs whose delayed appearance is dependent on proteins synthesized during the primary response. We isolated a 50-kb ecdysone-inducible gene, E75, that occupies the early puff locus at 75B. E75 contains two overlapping transcription units. The E75 A unit is a coextensive with the E75 gene and contains six exons: two 5'-proximal exons, A0 and A1, which are specific to this unit, and exons 2-5, which are common to both units. The E75 B unit is 20 kb long and contains five exons, a 5'-terminal exon, B1, located within the second intron of E75 A, and the common exons 2-5. Large open reading frames start within the first exon of each unit and continue into the last exon and therefore encode two different proteins. Both proteins exhibit sequence similarity to the conserv...Continue Reading

References

Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G K McMaster, G G Carmichael
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J M JeltschP Chambon
Apr 28, 1988·Nature·N BrandA Dejean
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J K BurmesterH F DeLuca
Nov 1, 1988·Trends in Genetics : TIG·S Green, P Chambon
Mar 22, 1985·Science·D J Lipman, W R Pearson
Jul 1, 1987·European Journal of Biochemistry·A Zahraoui, G Cuny
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C S HuckabyB W O'Malley
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M Johnston, J Dover
Aug 29, 1986·Cell·V GiguèreR M Evans
Jan 1, 1974·Cold Spring Harbor Symposia on Quantitative Biology·M AshburnerG Richards
Jul 11, 1984·Nucleic Acids Research·P O O'Connell, M Rosbash
May 5, 1984·Journal of Molecular Biology·W A SegravesB P Jarry
Jan 1, 1980·Methods in Enzymology·A M Maxam, W Gilbert
Oct 25, 1980·Journal of Molecular Biology·F SangerB A Roe
Jul 10, 1981·Nucleic Acids Research·D Ish-Horowicz, J F Burke
Mar 25, 1983·Nucleic Acids Research·L DenteR Cortese
Jan 1, 1983·Methods in Enzymology·J Messing

❮ Previous
Next ❯

Citations

Jan 1, 1996·Archives of Insect Biochemistry and Physiology·L M Riddiford
Jan 1, 1996·Archives of Insect Biochemistry and Physiology·E H Baehrecke
Jan 1, 1997·Archives of Insect Biochemistry and Physiology·S R PalliA Retnakaran
Dec 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C S Thummel
Aug 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C S Thummel
Jan 1, 1992·Developmental Genetics·J M James, G E Collier
Aug 1, 1991·Chromosoma·P Mavragani-Tsipidou, Z G Scouras
Jan 1, 1992·Parasitology Research·M Spindler-Barth
Dec 23, 1993·Biochimica Et Biophysica Acta·R Janknecht, A Nordheim
Jan 1, 1992·Experimental Gerontology·J W Truman
Jan 1, 1993·Mechanisms of Development·C K Ohno, M Petkovich
Nov 1, 1994·Mechanisms of Development·S TaravirasG Kelsey
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·K Dahlman-WrightJ A Gustafsson
Jan 1, 1993·Insect Biochemistry and Molecular Biology·P Cherbas
Jan 1, 1993·Insect Biochemistry and Molecular Biology·W A Segraves, C Woldin
Jan 1, 1993·Insect Biochemistry and Molecular Biology·R J HillE Macavoy
Jan 1, 1995·Insect Biochemistry and Molecular Biology·W L ChoA S Raikhel
Apr 1, 1995·Insect Biochemistry and Molecular Biology·K W DeitschA S Raikhel
Sep 1, 1994·Insect Biochemistry and Molecular Biology·M JindraL M Riddiford
Jun 1, 1995·Insect Biochemistry and Molecular Biology·S R PalliA Retnakaran
Jul 1, 1995·Insect Biochemistry and Molecular Biology·H FujiwaraL M Riddiford
Sep 1, 1995·Insect Biochemistry and Molecular Biology·V C Henrich, N E Brown
Jun 28, 2005·Insect Biochemistry and Molecular Biology·Stéphanie Auzoux-BordenaveStéphane Debernard
Jun 5, 2003·Developmental Biology·Geoffrey E StilwellLynn M Riddiford

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.