The early diagnosis of medullary carcinoma of the thyroid gland in patients with multiple endocrine neoplasia type II.

Annals of Surgery
S A WellsD C Sabiston

Abstract

Pentagastrin is a potent stimulator of thyrocalcitonin secretion from "C" cells. Since medulllary carcinoma of the thyroid gland (MCT) is a tumor composed of "C" cells, pentagastrin was used to screen a large kindred with multiple endocrine neoplasia type II (MCT, pheochromocytoma (s), and parathyroid hyperplasia). Four children with no thyroid abnormalities evident on physical examination, with negative thyroid scans, and with normal levels of plasma thyrocalcitonin both before and after calcium infusion, were found to have elevated peripheral levels of this hormone following pentagastrin injection. All four children were found to have very small foci of MCT, in both thyroid lobes at the time of total thyroidectomy. Pentagastrin stimulation used conjointly with selective catheterization of the inferior thyroid vein provided even greater diagnostic accuracy in detecting elevations in thyrocalcitonin secretion. This test has great diagnostic utility, especially in screening patients with multiple endocrine neoplasia type II.

References

Aug 30, 1973·The New England Journal of Medicine·H J WolfeA H Tashjian
Jan 1, 1973·The Journal of Clinical Endocrinology and Metabolism·J F HennessyD A Ontjes
Dec 3, 1970·The New England Journal of Medicine·S B BaylinA Sjoerdsma
Apr 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·K E Melvin, A H Tashjian
Aug 8, 1968·The New England Journal of Medicine·A H Tashjian, E W Melvin
Mar 1, 1969·Investigative Radiology·J L DoppmanW G Hammond
Jan 1, 1959·The Journal of Clinical Endocrinology and Metabolism·J B HAZARDG CRILE

❮ Previous
Next ❯

Citations

Dec 1, 1984·European Journal of Pediatrics·K FrankR Ziegler
Aug 1, 1986·World Journal of Surgery·A MiyauchiM Maeda
Jan 1, 1983·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M EricssonS Ingemansson
May 1, 1990·The Japanese Journal of Surgery·T ShimotakeS Takai
Oct 1, 1976·Journal of Pediatric Surgery·L L LeapeS Reichlin
Jul 18, 1976·The New England Journal of Medicine·S A WellsL M Sherwood
Nov 2, 1978·The New England Journal of Medicine·K GrazeS Reichlin
Feb 1, 1977·Annals of Surgery·M A Block
Feb 1, 1981·Postgraduate Medical Journal·J C StevensonB M Stevenson
Dec 1, 1979·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·W G WoodP C Scriba
Oct 27, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·W SchürchM Verdy
Jul 15, 1978·Klinische Wochenschrift·F RaueR Ziegler
Mar 22, 2012·Cytopathology : Official Journal of the British Society for Clinical Cytology·G C H YangP H Levine
Dec 1, 1977·American Journal of Surgery·C H Organ
Jul 1, 1990·Trends in Endocrinology and Metabolism : TEM·W B Carter, H Heath
Apr 1, 1980·American Journal of Surgery·R L RossiJ Werber
May 1, 1985·Current Problems in Surgery·W G Cance, S A Wells
Dec 1, 1982·The Journal of Pediatrics·R F GagelA H Tashjian
Jul 1, 1981·Clinics in Endocrinology and Metabolism·S B Baylin, S A Wells
Jan 1, 1989·Seminars in Surgical Oncology·J P Minton, A Chevinsky
Nov 1, 1977·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·T Normann
Jun 22, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Mara BăetuCorin Badiu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.