The early generation of a heterogeneous CD4+ T cell response to Leishmania major.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Sara L Colpitts, Phillip Scott

Abstract

CD4(+) T cells are an essential component of both the primary and secondary immune response against the intracellular protozoan parasite Leishmania major. Our laboratory has previously shown that CD62L(high) IL-7R(high) central memory T (T(CM)) cells mediate protective immunity following secondary challenge. To determine when T(CM) cells develop, we examined the phenotype of Leishmania-specific CD4(+) T cells in the first 2 wk following infection. As expected, we identified a population of CD4(+) T cells present in the draining lymph node with the characteristics of effector T cells. However, in addition, a second population phenotypically resembling T(CM) cells emerged coincident with the effector population. These T cells, expressing CD62L, CCR7, and IL-7R, failed to produce IFN-gamma, but had the capacity to give rise to IFN-gamma-producing effector cells. Our studies also demonstrated that the degree of proliferation and the timing of lymph node entry impact T(CM) cell development. The early generation of T(CM) cells following L. major infection indicates that T(CM) cells may not only control secondary infections, but may also contribute to the control of the primary infection.

References

Oct 18, 2000·The Journal of Experimental Medicine·R M KedlP Marrack
Mar 23, 2001·Nature Immunology·K S SchlunsL Lefrançois
Mar 10, 2001·Nature·R L ReinhardtM K Jenkins
Oct 3, 2001·The Journal of Experimental Medicine·A M DoyleS L Reiner
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Judith HarbertsonLinda M Bradley
Mar 6, 2002·The Journal of Experimental Medicine·Joseph N BlattmanRafi Ahmed
Oct 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hai-Hui XueWarren J Leonard
Dec 4, 2002·Nature Reviews. Immunology·Antonio Lanzavecchia, Federica Sallusto
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael J Fuller, Allan J Zajac
Dec 10, 2003·The Journal of Experimental Medicine·Robyn M KondrackLinda M Bradley
Dec 17, 2003·The Journal of Experimental Medicine·JiChu LiSusan L Swain
Mar 3, 2004·European Journal of Immunology·Ana Clara MisslitzToni Aebischer
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Katharina M HusterDirk H Busch
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gail A Corbin, John T Harty
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·E John WherryRafi Ahmed
Dec 18, 2004·Advances in Parasitology·Jean-Claude AntoineThierry Lang
Mar 30, 2005·The Journal of Experimental Medicine·Dawn M Jelley-GibbsSusan L Swain
Apr 16, 2005·Clinical Microbiology Reviews·Martin OlivierGeneviève Forget
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael J FullerAllan J Zajac
May 18, 2005·The Journal of Experimental Medicine·Reinhard ObstChristophe Benoist
Jul 19, 2005·Nature Immunology·Amanda L MarzoLeo Lefrançois
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin F BachmannAnnette Oxenius
Apr 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara PrickettDeborah F Smith
May 11, 2006·Trends in Immunology·Vaishali R Moulton, Donna L Farber
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Colby ZaphDavid Artis
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter M GrayPhillip Scott
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giandomenica IezziManfred Kopf
Jul 11, 2006·Immunological Reviews·Andrew M IntlekoferSteven L Reiner
Jul 27, 2006·Nature Reviews. Immunology·Leo Lefrançois, Amanda L Marzo
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kimberly D KlonowskiLeo Lefrançois
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pulak TripathiDavid A Hildeman
Jul 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Timothy W HandSusan M Kaech
Sep 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·David A Blair, Leo Lefrançois

❮ Previous
Next ❯

Citations

Jun 14, 2013·PloS One·Aaruni KhanolkarJohn T Harty
Jul 29, 2015·The Journal of Experimental Medicine·Nelson D GlenniePhillip Scott
Jul 19, 2016·Nature Reviews. Immunology·Phillip Scott, Fernanda O Novais
Dec 8, 2016·The Journal of Experimental Medicine·Simone A NishSteven L Reiner
Nov 24, 2017·Frontiers in Immunology·Rajiv KumarChristian R Engwerda
Mar 10, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas HolowkaRichard Bucala
Aug 26, 2020·Cold Spring Harbor Perspectives in Biology·Phillip Scott
Feb 28, 2020·Scientific Reports·Vinod KumarPradeep Das
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Thalia Pacheco-FernandezHira L Nakhasi
Jul 6, 2021·Parasitology·Sajad RashidiEugenio Antonio Carrera Silva

❮ Previous
Next ❯

Related Concepts

Related Feeds

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Colby ZaphDavid Artis
The Journal of Immunology : Official Journal of the American Association of Immunologists
Nazzy PakpourPhillip Scott
© 2021 Meta ULC. All rights reserved