The Early Metazoan Trichoplax adhaerens Possesses a Functional O-GlcNAc System.

The Journal of Biological Chemistry
Nithya SelvanDaan M F van Aalten

Abstract

Protein O-GlcNAcylation is a reversible post-translational signaling modification of nucleocytoplasmic proteins that is essential for embryonic development in bilateria. In a search for a reductionist model to study O-GlcNAc signaling, we discovered the presence of functional O-GlcNAc transferase (OGT), O-GlcNAcase (OGA), and nucleocytoplasmic protein O-GlcNAcylation in the most basal extant animal, the placozoan Trichoplax adhaerens. We show via enzymatic characterization of Trichoplax OGT/OGA and genetic rescue experiments in Drosophila melanogaster that these proteins possess activities/functions similar to their bilaterian counterparts. The acquisition of O-GlcNAc signaling by metazoa may have facilitated the rapid and complex signaling mechanisms required for the evolution of multicellular organisms.

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Citations

Aug 1, 2018·PLoS Biology·Michael EitelGert Wörheide
Oct 23, 2015·The Journal of Biological Chemistry·Adam OstrowskiDaan M F van Aalten
Apr 3, 2018·Genome Biology and Evolution·Ismail Sahin GulFrans van Roy
Feb 11, 2016·Biochemical Society Transactions·Riccardo TrapannoneDaan M F van Aalten

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Datasets Mentioned

BETA
OGA54

Methods Mentioned

BETA
PCR
size exclusion chromatography
Transgenic
protein assay
transfections
transfection
immunoprecipitation

Software Mentioned

ALINE
CLUSTALW
Prism
Click
BLAST
- It
PyMOL
XtalPred
GraphPad

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