The early pathogenesis of bovine mastitis due to Escherichia coli

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
A J FrostB E Brooker

Abstract

The pathogenesis of coliform mastitis was studied after infusing each of ten lactating quarters of three dairy cows with a large dose (ca. 1 x 10(9) colony-forming units) of virulent Escherichia coli strain B117. This approach was adopted first to maximize the chance of observing microscopic lesions in the tissues of a gland and secondly to overwhelm the differences that might be shown between animals in their response to the infection. The infected glands were examined at intervals of up to 4 h after infection by scanning and transmission electron microscopy and by light microscopy. The earliest lesions were seen after 1 h and consisted of necrosis and sloughing of the epithelial cells of the teat and lactiferous sinuses. After 2 h this was more severe, and was followed by an intense neutrophil response. Neutrophils migrated through the epithelial lesions and at first remained attached to the epithelial surface, forming large mounds. This resulted in gross underestimation of the number of cells in the lumen of the gland when neutrophils in the secretion were counted. At no stage was there evidence of attachment of organisms to the epithelial cells. Tissue damage did not extent beyond the basement membrane, which helps to expla...Continue Reading

References

Jun 1, 1977·Bacteriological Reviews·H Smith
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Nov 1, 1938·The Journal of Hygiene·A A MilesJ O Irwin

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Citations

Oct 5, 2011·Journal of Mammary Gland Biology and Neoplasia·R Michael Akers, Stephen C Nickerson
Apr 12, 2002·Veterinary Immunology and Immunopathology·Araceli Diez-FraileChristian Burvenich
Apr 1, 1983·Journal of Comparative Pathology·A J Frost, B E Brooker
Jun 1, 1986·Australian Veterinary Journal·S Sastrowidjojo, A J Frost
Jul 21, 2004·Journal of Dairy Science·F VangroenwegheC Burvenich
Sep 17, 1981·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B E BrookerA J Frost
Dec 1, 1991·Journal of Dairy Science·L A BabiukR Harland
Oct 1, 1986·Australian Veterinary Journal·A J Frost, B E Brooker
May 1, 1985·Australian Veterinary Journal·I G Colditz, D L Watson
Sep 1, 1988·Journal of Dairy Science·S P Oliver, L M Sordillo
Oct 17, 2001·Journal of the American Veterinary Medical Association·J R WenzR J Callan
Apr 14, 2006·Veterinary Research·Pascal Rainard, Céline Riollet
Sep 6, 2007·Journal of Animal Science·X Zhao, P Lacasse
Jun 1, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Xichun WangYu Li

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