The early phase of glucose-stimulated insulin secretion requires nitric oxide

Diabetologia
G A SpinasM Reinecke

Abstract

Nitric oxide (nitrogen monoxide, NO) acts as a signal transducer in a variety of cells. In the present study rat pancreatic islets were perifused with physiologically relevant glucose concentrations in the presence or absence of various NO-modulating agents. Perifusion in the presence of 0.1-1 mmol/l of the NO synthase inhibitor, NG-monomethyl-L-arginine or of 10 micromol/l of the NO-scavenger, 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO), resulted in an inhibition of the early phase of glucose-stimulated insulin secretion by 60-65% and 46%, respectively. Light- and electron-microscopic studies revealed that pancreatic islets constitutively express NO-synthase in alpha and delta cells, where it is confined to the secretory granules. Therefore, these data indicate that NO may be important in the signal transduction pathway of the early phase of glucose-stimulated insulin secretion.

Citations

May 22, 2002·Life Sciences·Fumi SuginoKoichi Nakayama
Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·David O Kennedy, Andrew B Scholey
Oct 18, 2001·Molecular and Cellular Endocrinology·P BeffyR Gross
Mar 12, 2011·The Journal of Biological Chemistry·Dean A WisemanDebbie C Thurmond
Aug 24, 2005·Acta Pharmacologica Sinica·Jing-tian XieChun-su Yuan
Feb 22, 2001·Biochemical and Biophysical Research Communications·A K AnderssonS Sandler
Mar 10, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fang YangNing Gu
Sep 12, 2007·Anatomia, histologia, embryologia·M B Arciszewski
Apr 17, 2014·Journal of Tissue Engineering and Regenerative Medicine·R A ZuelligR Lehmann
Apr 9, 2004·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·J T XieC S Yuan
Nov 29, 2013·Journal of Pharmacological Sciences·Yukiko Kurohane Kaneko, Tomohisa Ishikawa
Jun 1, 2014·Free Radical Biology & Medicine·Brian E Sansbury, Bradford G Hill
Jan 25, 2011·Diabetes Research and Clinical Practice·Mahdieh Mehrab-MohseniMahsa M Amoli
Mar 1, 2007·Diabetes·Roger LehmannGiatgen A Spinas
Mar 10, 2015·Cell Transplantation·Neha Jain, Eun Jung Lee
Oct 28, 2010·Diabetes·Veronika LeissRobert Lukowski
Nov 24, 2006·American Journal of Physiology. Endocrinology and Metabolism·Craig S NunemakerLeslie S Satin
Jun 26, 2020·Archives of Physiology and Biochemistry·Esther Oluwasola AlukoAdesoji Adedipe Fasanmade
Feb 22, 2001·American Journal of Physiology. Renal Physiology·S V BrodskyM S Goligorsky
Jun 11, 2002·American Journal of Physiology. Cell Physiology·Ragnar HenningssonIngmar Lundquist
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Giatgen A. Spinas
Jun 23, 2010·Ophthalmic Genetics·Javad Tavakkoly BazzazIan V Hutchinson
Jan 17, 2003·American Journal of Physiology. Cell Physiology·Yukiko KanekoKoichi Nakayama
Aug 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Zomorrod AtaieZahra Ghiravani
Dec 28, 2002·Diabetes Care·Adrien SchaeferGabrielle Brandenberger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.