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The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches

Biological Psychiatry

Dec 18, 2001

Jeffrey A LiebermanJohn H Gilmore

Abstract

Schizophrenia is commonly considered a neurodevelopmental disorder that is associated with significant morbidity; however, unlike other neurodevelopmental disorders, the symptoms of schizophrenia often do not manifest for decades. In most patients, the formal onset of schizophrenia is p...read more

Mentioned in this Paper

Antipsychotic Effect
Pathogenic Aspects
Atypical Antipsychotic [EPC]
N-acetylaspartate
Morbidity Aspects
Neurobehavioral Manifestations
Pathogenesis
Prefrontal Cortex
Schizophrenia
Pathogenic Organism
218
Paper Details
References
  • References37
  • Citations211
1234
  • References37
  • Citations211
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The Journal of Clinical Psychiatry

Neurobiology and the natural history of schizophrenia

The Journal of Clinical PsychiatryNovember 17, 2006
Jeffrey A Lieberman
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The early stages of schizophrenia: speculations on pathogenesis, pathophysiology, and therapeutic approaches

Biological Psychiatry

Dec 18, 2001

Jeffrey A LiebermanJohn H Gilmore

PMID: 11743943

DOI: 10.1016/s0006-3223(01)01303-8

Abstract

Schizophrenia is commonly considered a neurodevelopmental disorder that is associated with significant morbidity; however, unlike other neurodevelopmental disorders, the symptoms of schizophrenia often do not manifest for decades. In most patients, the formal onset of schizophrenia is p...read more

Mentioned in this Paper

Antipsychotic Effect
Pathogenic Aspects
Atypical Antipsychotic [EPC]
N-acetylaspartate
Morbidity Aspects
Neurobehavioral Manifestations
Pathogenesis
Prefrontal Cortex
Schizophrenia
Pathogenic Organism
218

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Neurodevelopmental disorder

Neurodevelopmental disorders such as attention deficit hyperactivity disorder (adhd) and autism spectrum disorder, although most commonly considered in childhood, can be lifelong conditions. Here is the latest research.

NMDA Receptor Signaling

The NDMA receptor is an ionotropic receptor that is activated when glutamate or glycine binds to it, initiating several downstream signaling cascades. NDMA receptor signaling is thought to be implicated in different pathologies, including depression. Here is the latest research on NDMA receptor signaling.

Related Papers

The Journal of Clinical Psychiatry

Neurobiology and the natural history of schizophrenia

The Journal of Clinical PsychiatryNovember 17, 2006
Jeffrey A Lieberman
Paper Details
References
  • References37
  • Citations211
1234
  • References37
  • Citations211
12345...
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