The early stages of the immune response of the European abalone Haliotis tuberculata to a Vibrio harveyi infection

Developmental and Comparative Immunology
Marion CardinaudChristine Paillard

Abstract

Vibrio harveyi is a marine bacterial pathogen responsible for episodic abalone mortalities in France, Japan and Australia. In the European abalone, V. harveyi invades the circulatory system in a few hours after exposure and is lethal after 2 days of infection. In this study, we investigated the responses of European abalone immune cells over the first 24 h of infection. Results revealed an initial induction of immune gene expression including Rel/NF-kB, Mpeg and Clathrin. It is rapidly followed by a significant immuno-suppression characterized by reduced cellular hemocyte parameters, immune response gene expressions and enzymatic activities. Interestingly, Ferritin was overexpressed after 24 h of infection suggesting that abalone attempt to counter V. harveyi infection using soluble effectors. Immune function alteration was positively correlated with V. harveyi concentration. This study provides the evidence that V. harveyi has a hemolytic activity and an immuno-suppressive effect in the European abalone.

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Citations

Jul 27, 2015·Journal of Invertebrate Pathology·Marie-Agnès TraversCarolyn S Friedman
Jul 19, 2016·Fish & Shellfish Immunology·Wan PengDan-Qi Lu
Jun 22, 2021·Developmental and Comparative Immunology·Rui XueJianmin Zhao

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